Αρχική World News Radionuclide Therapy Could Be A Viable Treatment For Early-Stage Breast Cancer, Study...

Radionuclide Therapy Could Be A Viable Treatment For Early-Stage Breast Cancer, Study Finds

Researchers have identified another potential therapy for early-stage breast cancer.Radionuclide therapy is a systemic (or whole-body) treatment that travels through the body via the bloodstream, like chemotherapy does. However, the radioactive substances in the treatment target diseased cells in particular, so side effects are greatly reduced (unlike chemotherapy).Roughly 20% of five-year breast cancer survivors will experience metastatic breast cancer sometime within five to ten years after treatment for the first occurrence of breast cancer. Metastatic breast cancer occurs when cancerous cells from the initial tumor break off and gain access to the circulatory system. From there, they can travel anywhere in the body. These cancerous cells are called disseminated tumor cells (DTCs). DTCs may immediately develop into tumors elsewhere in the body, or they may stay dormant for several years before suddenly becoming active.Photo: Adobe Stock/Alexander Oganezov
Researchers have found that radionuclide therapy can accurately target these DTCs and delay or stop their growth in early-stage breast cancer. Radionuclide therapy utilizes the alpha-particle-emitting radiopharmaceutical 223RaCl2 (Radium-233 dichloride). Not only can the treatment target DTCs, but it also is able to find and attack cancer cells that are outside of the immediate radiation field, called bystander cells.The study was published in the Journal of Nuclear Medicine. Researchers split female mice into three groups. First, each group was given either 0 kBq/kg (the control group), 50kBq/kg, or 600 kBq/kg of 223RaCl2 to create bystander conditions. Then, 24 hours later, the bone marrow of the mice were injected with human breast cancer cells that were either estrogen receptor-positive (ER+) or triple negative (which is not fueled by estrogen, progesterone, or HER2). The tumor cell count was measured on day one and then once a week after that to track growth.Photo: Adobe Stock/ Jennifer
Researchers found that DTCs were present in mice with both types of breast cancer. They found that mice with ER+ breast cancer had a 7-day growth delay in tumor progression when given 50 kBq/kg of 223RaCl2, and a 65-day growth delay when given 600 kBq/kg. The mice with triple negative breast cancer (TNBC) experienced a 10-day growth delay in tumor progression when given 600 kBq/kg. The mice with TNBC who were given 50 kBq/kg experienced no significant difference from the control group.“The increased magnitude of the bystander effect in this study suggests that higher injected activities may better sterilize undetected dormant or slow-growing DTCs in the bone marrow micro-environment,” said researchers.Photo: Adobe Stock/Gorodenkoff
Because of these promising results, researchers say it may eventually be an option for certain patients who are in the early stages of breast cancer.“This study adds to the mounting evidence that radiation-induced bystander effects can play a role in in the design of future treatment plans for radiopharmaceuticals alone or combined with external-beam therapy,” researchers said. “Furthermore, the capacity to target specific cells or tissues in a systemic manner may offer advantages over the use of external beams of radiation for eliciting therapeutic bystander responses.”Source

NEWSLETTER

Συμπληρώστε το email σας για να λαμβάνετε τις σημαντικότερες ειδήσεις από το ogkologos.com

Βρείτε μας

2,449ΥποστηρικτέςΚάντε Like
57ΑκόλουθοιΑκολουθήστε

Διαβαστε Επίσης

Καρκίνος και Κορωνοϊός (COVID-19) ΜΕΡΟΣ Α

Εάν είστε καρκινοπαθής, το ανοσοποιητικό σας σύστημα μπορεί να μην είναι τόσο ισχυρό όσο κανονικά, έτσι μπορεί να ανησυχείτε για τους κινδύνους που σχετίζονται...

ΠΑΓΚΟΣΜΙΑ ΗΜΕΡΑ ΚΑΡΚΙΝΟΥ

Η Παγκόσμια Ημέρα Κατά του Καρκίνου καθιερώθηκε με πρωτοβουλία της Διεθνούς Ένωσης κατά του Καρκίνου (UICC), που εκπροσωπεί 800 οργανώσεις σε 155 χώρες του...

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ)

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ) Γράφει ο Δρ Παπαδούρης Σάββας, Παθόλογος-Ογκολόγος   Ο ΜΜΚΠ βρίσκεται αναλογικά στο 80% και πλέον του συνολικού...

Διατρέχουν όντως οι καρκινοπαθείς μεγαλύτερο κίνδυνο λόγω κοροναϊού;

Σε πρακτικό επίπεδο, τα δεδομένα των σχετικών μελετών υποδηλώνουν ότι η χημειοθεραπεία ή οι άλλες αντι-νεοπλασματικές θεραπείες δεν αυξάνουν σημαντικά τον κίνδυνο θνησιμότητας από...

FDA: Η ακτινοβολία των smartphones δεν προκαλεί καρκίνο

Σε μια νέα έκθεσή της, η Υπηρεσία Τροφίμων και Φαρμάκων (FDA) των ΗΠΑ αναφέρει ότι επανεξέτασε τις σχετικές επιστημονικές έρευνες που δημοσιεύθηκαν τα τελευταία...

Νέα ανακάλυψη, νέα ελπίδα για τον καρκίνο

Ένα νεοανακαλυφθέν τμήμα του ανοσοποιητικού μας συστήματος θα μπορούσε να αξιοποιηθεί για την αντιμετώπιση όλων των ειδών καρκίνου, σύμφωνα με επιστήμονες του πανεπιστημίου Cardiff...
- Advertisment -

Ροή Ειδήσεων

Combining existing drugs improves prostate cancer survival

Adding abiraterone to standard hormone therapy improves survival for men with high-risk prostate cancer that’s not spread elsewhere in the body. “Today’s results are the...

New Combination of Old Drugs Improves Survival in Patients with Prostate Cancer [ESMO Congress 2021 Press Release]

LBA4_PR - Abiraterone acetate plus prednisolone (AAP) with or without enzalutamide (ENZ) added to androgen deprivation therapy (ADT) compared to ADT alone for men...

Immunotherapy Prolongs Survival in Recurrent, Persistent or Metastatic Cervical Cancer [ESMO Congress 2021 Press Release]

LBA2_PR - Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for persistent, recurrent, or metastatic cervical cancer: Randomized, double-blind, phase 3 KEYNOTE-826 study N. Colombo1, C....

Woman Diagnosed with Breast Cancer at 33 Launches Self-Examination App

Jessica Baladad has had a long history with self-examinations after a breast cancer scare in her early 20s. This habit helped save her life,...

Extended Adjuvant Treatment with Letrozole Results in Longer Survival in Postmenopausal Patients with Breast Cancer

According to results from a prospective, open-label, phase III study conducted in 69 Italian hospitals within the Gruppo Italiano Mammella among the postmenopausal patients...

Foodie Fridays: Apple Bok Choy Salad

While the temps may still be in the 80’s, apple season is upon us! Give this Apple Bok Choy salad a try!  It is...