Αρχική World News Mutation Screening Could Reveal Whether Hormone Treatment Will Work for Breast Cancer...

Mutation Screening Could Reveal Whether Hormone Treatment Will Work for Breast Cancer Patients

Different patients respond differently to different types of treatments, which is completely normal. But it sucks putting time, money, and effort into a treatment that may or may not do the job—especially if you’re trying to keep your cancer from spreading or recurring.

Most breast tumors have a high level of estrogen receptors, making them respond positively to anti-estrogen treatment. However, a small portion of women who undergo anti-estrogen treatment after breast cancer surgeries will find that their cancer gets worse or relapses with treatment. This is often due to mutations in the estrogen receptor gene that inhibit the activity of the medication.

Until recently, there was no way to tell whether a patient would get better or worse on this type of medication, leaving doctors and patients blindly guessing at their treatment plans.

Photo: Adobe Stock/Elnur

Article continues below

Our Featured Programs

See how we’re making a difference for People, Pets, and the Planet and how you can get involved!

Luckily, researchers believe they’ve found a way to determine whether these hormone treatments will work for an individual patient based on whether or not they have certain mutations in the estrogen receptor gene.

“We investigated whether the resistance mutations, which occurred before cancer treatment, affected the patients’ survival and saw that patients with a mutation in their primary tumor had three times higher risk of recurrence and 2.5 times higher risk of dying,” says doctoral student Malin Dahlgren. “The link between the mutations and poor survival was also seen after statistical corrections for age or for other factors that may affect the outcome for the patient.”

The study, conducted at Lund University and published in JNCI Cancer Spectrum, is the largest of its kind on resistance mutations in the estrogen receptor in primary breast cancer. It focused on the mutations in the estrogen receptor ESR1 gene, which is common in relapsed breast cancer in women who had received prior anti-estrogen cancer treatment.

Photo: Adobe Stock/Seventyfour

“If our results are confirmed in further studies, it would be relevant to screen for these resistance mutations already at diagnosis, and then consider other treatment options that could work better for patients with mutated tumors,” says Lao Saal, who led the study.

The researchers analyzed RNA-sequencing data from more than 3,000 untreated breast tumors from patients who participated in the large SCAN-B research project. 2,720 tumors were positive for estrogen receptors and therefore eligible for hormone treatment, while 29 tumors had an ESR1 resistance mutation. Resistance mutations were only found in patients over the age of 50.

Researchers noted that these mutations made the tumors resistant to hormonal treatments. Luckily, however, the chance of having a resistance mutation is very low in a patient who has only been diagnosed with cancer once.

Photo: Adobe Stock/lily

“This not only confirms what previous studies have shown, that the mutations are relatively rare, but we now show that these resistant mutations occur in about 1 percent of breast cancer cases already at initial diagnosis, and we are the first to show that these patients seem to respond less well to hormonal treatment. If the results can be verified in further studies, it may be relevant to consider other treatment options for these patients,” concludes Lao Saal.

If these results are corroborated in further studies, then testing for resistance mutations could become commonplace and could save certain breast cancer patients time and money on cancer treatments that aren’t likely to work well for them.

Provide Mammograms

Support those fighting Breast Cancer at The Breast Cancer Site for free!

Whizzco Source

NEWSLETTER

Συμπληρώστε το email σας για να λαμβάνετε τις σημαντικότερες ειδήσεις από το ogkologos.com

Βρείτε μας

2,449ΥποστηρικτέςΚάντε Like
57ΑκόλουθοιΑκολουθήστε

Διαβαστε Επίσης

Καρκίνος και Κορωνοϊός (COVID-19) ΜΕΡΟΣ Α

Εάν είστε καρκινοπαθής, το ανοσοποιητικό σας σύστημα μπορεί να μην είναι τόσο ισχυρό όσο κανονικά, έτσι μπορεί να ανησυχείτε για τους κινδύνους που σχετίζονται...

ΠΑΓΚΟΣΜΙΑ ΗΜΕΡΑ ΚΑΡΚΙΝΟΥ

Η Παγκόσμια Ημέρα Κατά του Καρκίνου καθιερώθηκε με πρωτοβουλία της Διεθνούς Ένωσης κατά του Καρκίνου (UICC), που εκπροσωπεί 800 οργανώσεις σε 155 χώρες του...

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ)

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ) Γράφει ο Δρ Παπαδούρης Σάββας, Παθόλογος-Ογκολόγος   Ο ΜΜΚΠ βρίσκεται αναλογικά στο 80% και πλέον του συνολικού...

Διατρέχουν όντως οι καρκινοπαθείς μεγαλύτερο κίνδυνο λόγω κοροναϊού;

Σε πρακτικό επίπεδο, τα δεδομένα των σχετικών μελετών υποδηλώνουν ότι η χημειοθεραπεία ή οι άλλες αντι-νεοπλασματικές θεραπείες δεν αυξάνουν σημαντικά τον κίνδυνο θνησιμότητας από...

FDA: Η ακτινοβολία των smartphones δεν προκαλεί καρκίνο

Σε μια νέα έκθεσή της, η Υπηρεσία Τροφίμων και Φαρμάκων (FDA) των ΗΠΑ αναφέρει ότι επανεξέτασε τις σχετικές επιστημονικές έρευνες που δημοσιεύθηκαν τα τελευταία...

Νέα ανακάλυψη, νέα ελπίδα για τον καρκίνο

Ένα νεοανακαλυφθέν τμήμα του ανοσοποιητικού μας συστήματος θα μπορούσε να αξιοποιηθεί για την αντιμετώπιση όλων των ειδών καρκίνου, σύμφωνα με επιστήμονες του πανεπιστημίου Cardiff...
- Advertisment -

Ροή Ειδήσεων

Despite Proven Safety of HPV Vaccines, More Parents Have Concerns

October 22, 2021, by NCI Staff Credit: National Cancer Institute Despite more than 15 years of consistent evidence that HPV vaccines are safe and effective, a...

FDA Approves Atezolizumab as Adjuvant Treatment for Non-Small Cell Lung Cancer

On 15 October 2021, the US Food and Drug Administration (FDA) approved atezolizumab (Tecentriq, Genentech, Inc.) for adjuvant treatment following resection and platinum-based chemotherapy...

Breast Cancer Survivor Uses Comedy to Spread Awareness and Address Disparities

Suzette Simon lost her mother to breast cancer. In 2020, she learned that she had the disease, as well. Realizing how much harder breast...

Why Wearing Comfortable Clothes During Cancer Treatment Matters

Voices on Cancer is an award-winning Cancer.Net Blog series where advocates share their stories and the lessons they have learned about being a cancer advocate. Cindy Trice is...

Breast cancer surgery: ‘I’m proud of the tattoos inked across my chest’

Wendy had a double mastectomy in 2017 and remained flat. “When the consultant told me, I remember crying and saying that I have 2 young...

EMA Recommends Granting a Marketing Authorisation for Zanubrutinib for the Treatment of Waldenström’s Macroglobulinaemia

On 16 September 2021, the European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use adopted a positive opinion, recommending the granting of...