Αρχική Uncategorized Regular Exercise May Boost Immune Response and Improve Immunotherapy in Breast Cancer...

Regular Exercise May Boost Immune Response and Improve Immunotherapy in Breast Cancer Patients

Regular weekly exercise has long been encouraged to remain in optimum health, as well as to help lessen the severity of certain illnesses. A new study has found that it may also help improve immune system response in women with breast cancer.

A team of researchers from Massachusetts General Hospital and Harvard Medical School looked at the impact exercise training had on mouse models of human breast cancer. They found that exercise helped slow tumor growth and improve outcomes, especially for those treated with immunotherapy drugs, because it stimulated naturally occurring immune responses. The study’s results were recently published in the journal Cancer Immunology Research.

PHOTO: ADOBE STOCK/WAVEBREAKMEDIAMICRO

Dr. Dai Fukumura, who co-authored the study and serves as deputy director of the Edwin L. Steele Laboratories in the Department of Radiation Oncology at MGH, says, “The most exciting finding was that exercise training brought into tumors immune cells capable of killing cancer cells known as cytotoxic T lymphocytes (CD8+ T cells) and activated them.”

The study showed that mice that did regular aerobic exercise had slower tumor growth than mice that were sedentary, and their immune systems had a stronger anti-tumor response through CD8+ T cells. When researchers suppressed those cells, the tumors grew at the same rate as those in the other mice. Researchers said this response appeared to be dependent on two chemical recruiters or chemokines known as CXCL9 and CXCL11. When mice exercised, the two chemokines were higher, except in those that were genetically engineered to lack the receptor for them.

Study co-author Dr. Rakesh Jain, director of the Steele Labs at MGH and professor of radiation oncology at HMS, says, “Humans whose tumors have higher levels of CD8+ T cells tend to have a better prognosis, respond better to treatment, and have reduced risk of cancer recurrence compared with patients whose tumors have lower levels of the immune cells, effects that were echoed by a reduced incidence of metastasis, or spread, of the cancers in mice that exercised.”

PHOTO: ADOBE STOCK/WAVEBREAK3

CD8+ T cells are also important in order for immune checkpoint inhibitor treatments to work. The study authors explain that this type of treatment has not yet had widespread success with breast cancer. However, when coupled with exercise, the study showed the treatment benefits were boosted.

Lead author Dr. Igor Gomes-Santos, who is also an exercise physiologist and post-doctoral fellow in the Steele Labs, says, “We showed that daily sessions of a moderate-to-vigorous intensity, continuous aerobic exercise training, lasting 30-45 minutes per session, induces a profound reprogramming of the tumor microenvironment that rewires tumor immunity, recruiting and activating CD8+ T cells to an unprecedented level with a non-pharmacological approach. Similar exercise training could be prescribed to a patient referred to an exercise oncology program.”

The team says that because there is currently more focus on general quality of life than on improved immunotherapy treatments, more evidence is needed to encourage oncologists to discuss exercise training with their patients and to expand exercise programs for those battling cancer.

Exercise may be key in avoiding a cancer return, as well. The National Cancer Institute says women who exercised regularly before and after treatment for high-risk breast cancer were found to have a lower chance of a recurrence.

PHOTO: ADOBE STOCK/WAVEBREAK3

Provide Mammograms

Support those fighting Breast Cancer at The Breast Cancer Site for free!

Whizzco Source

NEWSLETTER

Συμπληρώστε το email σας για να λαμβάνετε τις σημαντικότερες ειδήσεις από το ogkologos.com

Βρείτε μας

2,449ΥποστηρικτέςΚάντε Like
57ΑκόλουθοιΑκολουθήστε

Διαβαστε Επίσης

Καρκίνος και Κορωνοϊός (COVID-19) ΜΕΡΟΣ Α

Εάν είστε καρκινοπαθής, το ανοσοποιητικό σας σύστημα μπορεί να μην είναι τόσο ισχυρό όσο κανονικά, έτσι μπορεί να ανησυχείτε για τους κινδύνους που σχετίζονται...

ΠΑΓΚΟΣΜΙΑ ΗΜΕΡΑ ΚΑΡΚΙΝΟΥ

Η Παγκόσμια Ημέρα Κατά του Καρκίνου καθιερώθηκε με πρωτοβουλία της Διεθνούς Ένωσης κατά του Καρκίνου (UICC), που εκπροσωπεί 800 οργανώσεις σε 155 χώρες του...

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ)

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ) Γράφει ο Δρ Παπαδούρης Σάββας, Παθόλογος-Ογκολόγος   Ο ΜΜΚΠ βρίσκεται αναλογικά στο 80% και πλέον του συνολικού...

Διατρέχουν όντως οι καρκινοπαθείς μεγαλύτερο κίνδυνο λόγω κοροναϊού;

Σε πρακτικό επίπεδο, τα δεδομένα των σχετικών μελετών υποδηλώνουν ότι η χημειοθεραπεία ή οι άλλες αντι-νεοπλασματικές θεραπείες δεν αυξάνουν σημαντικά τον κίνδυνο θνησιμότητας από...

FDA: Η ακτινοβολία των smartphones δεν προκαλεί καρκίνο

Σε μια νέα έκθεσή της, η Υπηρεσία Τροφίμων και Φαρμάκων (FDA) των ΗΠΑ αναφέρει ότι επανεξέτασε τις σχετικές επιστημονικές έρευνες που δημοσιεύθηκαν τα τελευταία...

Νέα ανακάλυψη, νέα ελπίδα για τον καρκίνο

Ένα νεοανακαλυφθέν τμήμα του ανοσοποιητικού μας συστήματος θα μπορούσε να αξιοποιηθεί για την αντιμετώπιση όλων των ειδών καρκίνου, σύμφωνα με επιστήμονες του πανεπιστημίου Cardiff...
- Advertisment -

Ροή Ειδήσεων

Overall Breast Cancer Incidence Down Since 1999, Rates Increase for Women Under 40

U.S. breast cancer death rates decreased by about 1% per year between 2013 and 2018. What were the new case rates during that same...

Impressive Responses to PD-1 Blockade in a Large Cohort of Children and Young Adults with Recurrent/Progressive Germline DNA Replication Repair-Deficient Cancers

A large, observational, registry-based study that leveraged systematically collected data gathered both retrospectively and prospectively through the International Replication Repair Deficiency Consortium reveals impressive...

2-Year-Boy Is So Excited To See Himself In Disney’s ‘Encanto’

The importance of representation in media has been a growing topic of concern, and companies have responded by adding more diversity to their characters,...

Man Walks Entire Continent To Spread Awareness About Mental Health & Suicide Prevention

Matthew Fennell is walking over 3,000 miles across Australia for an important cause and one that is near and dear to his heart. Last year,...

Boy Battling Cancer Becomes Honorary Police Officer, Sworn In To 45 Agencies

At just ten years old, Devarjaye “DJ” Daniel has already been through more than most people go through in their entire lives. DJ has been...

Paclitaxel and Carboplatin Not Inferior When Compared with Paclitaxel and Ifosfamide for the Treatment of Patients with Uterine Carcinosarcoma

With regard to overall survival (OS), paclitaxel and carboplatin was not inferior and demonstrated improved progression-free survival (PFS) when compared with paclitaxel and ifosfamide...