Αρχική World News Activity of Targeted/Immune Therapy Approach in Patients with Advanced Urothelial Cancer

Activity of Targeted/Immune Therapy Approach in Patients with Advanced Urothelial Cancer

Prof. Thomas Powles of the Barts Cancer Institute, Queen Mary University of London, Barts Cancer Centre in London, UK and BISCAY investigators combined durvalumab with relevant targeted therapies in biomarker-selected chemotherapy-refractory advanced urothelial cancer populations. Their data support the clinical activity of fibroblast growth factor receptor (FGFR) inhibition and durvalumab monotherapy, but do not show increased activity for any of the combinations. The findings are published in a letter in the Nature Medicine on 3 May 2021.

The authors wrote in the background that durvalumab is a programmed death-ligand 1 (PD-L1) inhibitor with clinical activity in advanced urothelial cancer. Advanced urothelial cancer is also characterised by several recurrent targetable genomic alterations.

BISCAY is an open-label, randomised, multi-drug, biomarker-directed, phase Ib study conducted in patients with muscle invasive bladder cancer. The study team combined durvalumab with relevant targeted therapies in biomarker-selected chemotherapy-refractory advanced urothelial cancer populations including FGFR inhibitors in tumours with FGFR DNA alterations, PARP inhibitor in tumours with and without DNA homologous recombination repair deficiency and TORC1/2 inhibitors in tumours with DNA alteration to the mTOR/PI3K pathway.

This study adopted a new, biomarker-driven, multi-arm adaptive design. Safety, efficacy and relevant biomarkers were evaluated. Overall, 391 patients were screened of whom 135 were allocated to one of six study arms.

Response rates ranged from 9% to 36% across the study arms, which did not meet efficacy criteria for further development.

Overall survival and progression-free survival were similar in the combination arms and durvalumab monotherapy arm.

Biomarker analysis showed a correlation between circulating plasma-based DNA (ctDNA) and tissue for FGFR alterations. Sequential ctDNA analysis showed that changes to FGFR alterations correlated with clinical outcome.

The authors concluded that their data support the clinical activity of FGFR inhibition and durvalumab monotherapy, but do not show increased activity for any of the combinations. These findings are relevant in terms of the question about the targeted/immune therapy approach in advanced urothelial cancer.

The study was sponsored by AstraZeneca.

Reference

Powles T, Carroll D, Chowdhury S, et al. An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer. Nature Medicine; Published online 3 May 2021. DOI: https://doi.org/10.1038/s41591-021-01317-6

Source

Προηγούμενο άρθροBRCA Gene Testing: Risks, Benefits, Costs, and Coverage
Επόμενο άρθροIt Might Sound Trite But…

NEWSLETTER

Συμπληρώστε το email σας για να λαμβάνετε τις σημαντικότερες ειδήσεις από το ogkologos.com

Βρείτε μας

2,449ΥποστηρικτέςΚάντε Like
57ΑκόλουθοιΑκολουθήστε

Διαβαστε Επίσης

Καρκίνος και Κορωνοϊός (COVID-19) ΜΕΡΟΣ Α

Εάν είστε καρκινοπαθής, το ανοσοποιητικό σας σύστημα μπορεί να μην είναι τόσο ισχυρό όσο κανονικά, έτσι μπορεί να ανησυχείτε για τους κινδύνους που σχετίζονται...

ΠΑΓΚΟΣΜΙΑ ΗΜΕΡΑ ΚΑΡΚΙΝΟΥ

Η Παγκόσμια Ημέρα Κατά του Καρκίνου καθιερώθηκε με πρωτοβουλία της Διεθνούς Ένωσης κατά του Καρκίνου (UICC), που εκπροσωπεί 800 οργανώσεις σε 155 χώρες του...

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ)

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ) Γράφει ο Δρ Παπαδούρης Σάββας, Παθόλογος-Ογκολόγος   Ο ΜΜΚΠ βρίσκεται αναλογικά στο 80% και πλέον του συνολικού...

Διατρέχουν όντως οι καρκινοπαθείς μεγαλύτερο κίνδυνο λόγω κοροναϊού;

Σε πρακτικό επίπεδο, τα δεδομένα των σχετικών μελετών υποδηλώνουν ότι η χημειοθεραπεία ή οι άλλες αντι-νεοπλασματικές θεραπείες δεν αυξάνουν σημαντικά τον κίνδυνο θνησιμότητας από...

FDA: Η ακτινοβολία των smartphones δεν προκαλεί καρκίνο

Σε μια νέα έκθεσή της, η Υπηρεσία Τροφίμων και Φαρμάκων (FDA) των ΗΠΑ αναφέρει ότι επανεξέτασε τις σχετικές επιστημονικές έρευνες που δημοσιεύθηκαν τα τελευταία...

Νέα ανακάλυψη, νέα ελπίδα για τον καρκίνο

Ένα νεοανακαλυφθέν τμήμα του ανοσοποιητικού μας συστήματος θα μπορούσε να αξιοποιηθεί για την αντιμετώπιση όλων των ειδών καρκίνου, σύμφωνα με επιστήμονες του πανεπιστημίου Cardiff...
- Advertisment -

Ροή Ειδήσεων

Despite Proven Safety of HPV Vaccines, More Parents Have Concerns

October 22, 2021, by NCI Staff Credit: National Cancer Institute Despite more than 15 years of consistent evidence that HPV vaccines are safe and effective, a...

FDA Approves Atezolizumab as Adjuvant Treatment for Non-Small Cell Lung Cancer

On 15 October 2021, the US Food and Drug Administration (FDA) approved atezolizumab (Tecentriq, Genentech, Inc.) for adjuvant treatment following resection and platinum-based chemotherapy...

Breast Cancer Survivor Uses Comedy to Spread Awareness and Address Disparities

Suzette Simon lost her mother to breast cancer. In 2020, she learned that she had the disease, as well. Realizing how much harder breast...

Why Wearing Comfortable Clothes During Cancer Treatment Matters

Voices on Cancer is an award-winning Cancer.Net Blog series where advocates share their stories and the lessons they have learned about being a cancer advocate. Cindy Trice is...

Breast cancer surgery: ‘I’m proud of the tattoos inked across my chest’

Wendy had a double mastectomy in 2017 and remained flat. “When the consultant told me, I remember crying and saying that I have 2 young...

EMA Recommends Granting a Marketing Authorisation for Zanubrutinib for the Treatment of Waldenström’s Macroglobulinaemia

On 16 September 2021, the European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use adopted a positive opinion, recommending the granting of...