Αρχική World News Treatment for Children with Leukemia Also Effective for Adolescents, Young Adults

Treatment for Children with Leukemia Also Effective for Adolescents, Young Adults

February 25, 2019, by NCI Staff

Wendy Stock, M.D., of the University of Chicago, and her patient Jenn Ferguson.

Jenn Ferguson (left), one of the first patients treated on the CALGB 10403 trial, and Wendy Stock, M.D. During treatment, Ferguson continued her education and went on to earn a professional degree, marry, and become a proud mother of two.

Credit: University of Chicago

An intensive treatment regimen developed specifically for children with acute lymphoblastic leukemia (ALL) is also effective for older adolescents and young adults (AYAs) with the disease, according to new results from a clinical trial.

In the trial, the use of an intensive pediatric treatment regimen led to better outcomes for AYA patients with newly diagnosed ALL, compared with outcomes for AYA patients with ALL who were treated with an adult regimen in previous clinical trials—a group known as historical controls.

The pediatric regimen more than doubled the median length of time patients went without experiencing debilitating symptoms or a return of the cancer, a measure known as event-free survival. In the trial, called CALGB 10403, the median event-free survival was 78.1 months, compared with 30 months for historical controls, researchers reported in Blood on January 18.

“The CALGB 10403 study demonstrated that it is both effective and feasible to treat young adults up to age 40 with a pediatric regimen administered by medical hematologists/oncologists” who do not specialize in pediatric cancer, said Wendy Stock, M.D., of the University of Chicago Comprehensive Cancer Center, who led the trial.

Compared with treatment regimens for adults with ALL, the pediatric regimen includes more intensive dosing of certain drugs as well as more prolonged and concentrated treatments to stop the disease from spreading to the brain and spinal cord.

Wendy Stock, M.D., with Jenn Ferguson and her baby son Dexter.

Wendy Stock, M.D. (left), and Jenn Ferguson holding son Dexter (now age 3).

Credit: Jenn Ferguson

Most children who receive the intensive regimen are treated by experienced pediatric oncologists at pediatric cancer centers. Until the current trial, researchers had not known whether AYA patients could tolerate the intensive pediatric regimen and whether hematologists and oncologists who treat adults could administer the intensive regimen as effectively as pediatric oncologists do.

Those questions have now been answered, according to Nita Seibel, M.D., head of Pediatric Solid Tumor Therapeutics in NCI’s Cancer Therapy Evaluation Program, who was not involved in the study.

“The pediatric regimen will become the new standard treatment for young adults who are newly diagnosed with ALL,” Dr. Seibel said. “And, as we try to improve the treatment for ALL, this regimen will be the treatment against which other therapies are compared.”

Testing an Intensive Therapy in AYA Patients

The pediatric regimen was identical to one used in a Children’s Oncology Group trial called AALL0232. The regimen includes, among other drugs, escalating doses of methotrexate followed by PEG-asparaginase.

Although up to 90% of children with ALL who receive intensive treatment are cured of the disease, AYAs have historically had worse outcomes, with event-free survival rates of 30% to 45%, the study authors noted.

Dr. Stock and her colleagues developed the current clinical trial after observing more than a decade ago that some AYA patients with ALL fared better on pediatric treatment regimens than on adult regimens.

To test this observation in a prospective trial, three NCI-supported clinical trials groups analyzed 295 patients aged 17–39 years old with newly diagnosed ALL who were treated with the intensive pediatric regimen. The median age of the participants was 24.

After a median follow-up of more than 5 years, 190 patients (64%) were alive and 105 patients (36%) had died.

The estimated 3-year overall survival to date is 73%, compared with a 3-year overall survival rate of 58% for historical control patients aged 16–29 years. The median overall survival for the study had not yet been reached at the time of publication.

There were eight treatment-related deaths during the trial, which translated into a treatment-related mortality rate of 3%—the same rate as that in previous pediatric trials of ALL.

“We had no more deaths due to treatment than we see in pediatric patients with newly diagnosed ALL, but we did have some increased side effects, as we expected with the intensive treatment regimen applied to young adults,” said Dr. Stock.

For instance, in the CALGB 10403 study, there was a higher incidence of certain complications—including those involving the liver—during the initial part of the treatment regimen, called induction therapy, than was seen in the AALL0232 study.

“There was evidence of more side effects in some patients, but the oncologists on the trial were able to make adjustments and deliver the therapy as it was supposed to be delivered,” Dr. Seibel said.

Predicting the Response to Therapy

Patients in the study who were obese, “and particularly those who were very obese, had worse outcomes than other patients,” Dr. Stock said. Nearly a third of the patients in the trial had a body mass index of 30 or higher, which is considered obese.

“The impact of obesity on the outcomes of patients was dramatic,” Dr. Stock added, noting that more research is needed to understand the reasons for this association.

“We are not sure why obese patients do worse than other patients, and that’s something we want to investigate in AYA patients,” said Dr. Seibel.

Previous studies of patients with ALL had identified another risk factor for worse outcomes: the presence in tumors of a gene expression profile called the Philadelphia chromosome-like gene signature. (This is similar to a profile in tumors with a genetic change known as the Philadelphia chromosome).

“We confirmed that finding in our study,” said Dr. Stock.

Building on the Current Regimen

As in previous trials, the researchers found that patients who had no detectable cancer cells (known as minimal residual disease) after induction chemotherapy had excellent survival rates. In the current study, however, a smaller percentage of AYA patients had no minimal residual disease, compared with previous trials involving children with ALL.

The higher incidence of the Philadelphia chromosome–like gene-expression signature among the AYA population may have contributed to the lower rate of no minimal residual disease in the current study, the study authors noted.

The lower rate of patients with no minimal residual disease after induction therapy also emphasizes “the need to consider the addition of new agents that might overcome treatment resistance,” the authors wrote. An example of this approach, they went on, is a clinical trial testing the addition of a targeted therapy called inotuzumab ozogamicin to the 10403 backbone in AYA patients.

Increasing Awareness among Physicians

Preliminary results from the trial have been presented at scientific meetings in the past, so many pediatric oncologists are aware of the work, though some medical oncologists in community settings may not be familiar with the findings, Dr. Seibel said.

“We’ve been waiting for the final results,” she continued. “It’s important to make sure that medical oncologists are aware of this study so that they don’t use the adult-based protocols for patients in this age group.”

Meanwhile, as the trial involving inotuzumab ozogamicin illustrates, researchers are building on the current study to further improve outcomes.

“There’s been tremendous progress in the treatment of ALL,” said Dr. Stock. “But we still have challenges ahead in terms of further improving survival and decreasing side effects for young adults with the disease.”

She added: “Our next generation of trials are already aiming towards these goals.”

Source

NEWSLETTER

Συμπληρώστε το email σας για να λαμβάνετε τις σημαντικότερες ειδήσεις από το ogkologos.com

Βρείτε μας

2,449ΥποστηρικτέςΚάντε Like
57ΑκόλουθοιΑκολουθήστε

Διαβαστε Επίσης

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ)

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ) Γράφει ο Δρ Παπαδούρης Σάββας, Παθόλογος-Ογκολόγος   Ο ΜΜΚΠ βρίσκεται αναλογικά στο 80% και πλέον του συνολικού...

Διατρέχουν όντως οι καρκινοπαθείς μεγαλύτερο κίνδυνο λόγω κοροναϊού;

Σε πρακτικό επίπεδο, τα δεδομένα των σχετικών μελετών υποδηλώνουν ότι η χημειοθεραπεία ή οι άλλες αντι-νεοπλασματικές θεραπείες δεν αυξάνουν σημαντικά τον κίνδυνο θνησιμότητας από...

FDA: Η ακτινοβολία των smartphones δεν προκαλεί καρκίνο

Σε μια νέα έκθεσή της, η Υπηρεσία Τροφίμων και Φαρμάκων (FDA) των ΗΠΑ αναφέρει ότι επανεξέτασε τις σχετικές επιστημονικές έρευνες που δημοσιεύθηκαν τα τελευταία...

Νέα ανακάλυψη, νέα ελπίδα για τον καρκίνο

Ένα νεοανακαλυφθέν τμήμα του ανοσοποιητικού μας συστήματος θα μπορούσε να αξιοποιηθεί για την αντιμετώπιση όλων των ειδών καρκίνου, σύμφωνα με επιστήμονες του πανεπιστημίου Cardiff...

Καρκίνος: Ευεργετική για τους καρκινοπαθείς η άσκηση

Σημαντικά ωφέλη προσφέρει η άσκηση, ακόμη και σε ασθενείς με καρκίνο. Οι περισσότεροι ασθενείς αγνοούν τα οφέλη που μπορεί να έχει γι’ αυτούς η συχνή...

Prostate Cancer

The article is provided by Scientific Communications Officer of NIPD Genetics, Ms Marina Charitou (MSc) Prostate Cancer Awareness Prostate cancer is the second most common cancer...
- Advertisment -

Ροή Ειδήσεων

ESMO 2020: New Treatments for Advanced Kidney Cancer, Prostate Cancer, and Bladder Cancer

The 2020 European Society for Medical Oncology (ESMO) Virtual Congress was held online from September 19 to September 21. In this podcast, Neeraj Agarwal,...

The UK Government’s spending review: Time to invest in the future of cancer care

This autumn, the chancellor Rishi Sunak will go to Parliament and set out the UK Government’s spending priorities in the Comprehensive Spending Review...

FDA Extends Approval of Pembrolizumab for Classical Hodgkin Lymphoma

On 14 October 2020, the US Food and Drug Administration (FDA) extended the approval of pembrolizumab (KEYTRUDA®, Merck Sharp & Dohme Corp.) for the...

31-Year-Old Mother Dies of Cancer After Her Chemotherapy Was Paused During the Pandemic

The COVID-19 pandemic has been a scary and difficult thing for most of the world, and it’s important to keep safety protocols in place...

For Esophageal Cancer, Immunotherapy Likely to Play Larger Role

October 19, 2020, by NCI Staff An esophagram using barium contrast shows the esophagus. Credit: iStock Immunotherapy may become part of early treatment for some people with...

Targeted Therapy Based on Molecular Profiling of Malignant Mesothelioma Tumours Is Feasible

Targeted therapy recommendations can be made based on the molecular profiles of tumour samples from patients with metastatic malignant mesothelioma (MM) according to findings...