2021 ASCO Annual Meeting Research Round Up: Advances in Treating Lung Cancer, Breast Cancer, and Sarcoma

In the annual Research Round Up series, Cancer.Net Associate Editors answer the question, “What was the most exciting or practice-changing research in your field presented at the 2021 ASCO Annual Meeting?” In this episode, 3 experts discuss new research from the meeting in lung cancer, breast cancer, and sarcoma.

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Research on new treatments for non-small cell lung cancer

Dr. Charu AggarwalDr. Charu Aggarwal, the 2021 Cancer.Net Associate Editor for Lung Cancer, discusses results from 3 studies evaluating new treatments for non-small cell lung cancer (NSCLC). First, she discusses the phase 2 CodeBreaK 100 clinical trial, which evaluated whether using the targeted therapy sotorasib (Lumakras) to treat people with metastatic non-small cell lung cancer with a KRAS G12C mutation shrank the tumors. [2:35] Next, she discusses a 5-year update from the phase 3 PACIFIC clinical trial on whether treating people with stage III (3) non-small cell lung cancer using the immunotherapy durvalumab (Imfinzi) following chemotherapy with radiation therapy helped them live longer. [4:46] Finally, she discusses the phase 3 Impower010 clinical trial, which tested whether treating people with early-stage non-small cell lung cancer with the immunotherapy atezolizumab (Tecentriq) following surgery and chemotherapy reduced their risk of recurrence, or the cancer coming back. [6:46]

Advances in treating early-stage breast cancer

Dr. Lynn HenryDr. Lynn Henry, the 2021 Cancer.Net Associate Editor for Breast Cancer, discusses results from 2 studies in breast cancer, the first of which was the phase 3 OlympiA clinical trial. In this study, researchers were evaluating whether treating people with a BRCA mutation and early-stage, HER2-negative breast cancer using olaparib (Lynparza), a type of targeted therapy called a PARP inhibitor, decreased the likelihood of the cancer returning. [10:40] Dr. Henry also discusses the final results from the phase 3 PROMISE-GIM6 clinical trial. Sometimes, ovarian suppression is given to preserve a patient’s ability to have children, or fertility, after treatment with chemotherapy ends. This trial was observing whether ovarian suppression combined with chemotherapy impacted a patient’s risk of recurrence. [12:47]

Research highlights for the treatment of sarcoma

Dr. Vicki KeedyDr. Vicki Keedy, the 2021 Cancer.Net Associate Editor for Sarcoma, discusses results from 2 studies testing new treatments for sarcoma. The first study, the phase 2 SPEARHEAD-1 clinical trial, looked at whether treating people with metastatic synovial sarcoma or myxoid/round cell liposarcoma using afami-cel, a type of immunotherapy called T-cell receptor therapy, shrank the tumors. [15:38] The second study evaluated whether treating people with metastatic synovial sarcoma using catequentinib, a type of targeted therapy called a tyrosine kinase inhibitor, slowed down their tumor growth compared to treatment with the chemotherapy dacarbazine (DTIC). [18:42]

Disclosure information for this podcast’s speakers can be found in their individual biographies, which are linked to in the paragraphs above.

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