Αρχική World News Pregnancy is Safe After Early Breast Cancer in Young Women with Germline...

Pregnancy is Safe After Early Breast Cancer in Young Women with Germline BRCA Mutations

Results from the largest study to date specifically designed to address several unmet questions related to the safety of pregnancy after breast cancer in women with germline BRCA mutations and their reproductive outcomes are published on 16 July 2020 in the Journal of Clinical Oncology. The study findings provide reassuring evidence that pregnancy after early breast cancer in women with germline BRCA mutations is safe without worsening of maternal prognosis and it is associated with favourable foetal outcomes. The findings are of paramount importance for healthcare providers involved in counselling young women with BRCA-mutated breast cancer who are interested about the feasibility and safety of future conception.

The authros wrote in the study background that due to current trend toward delaying childbearing, increasing numbers of young women are diagnosed with breast cancer before the completion of their reproductive plans. Pregnancy in women with a history of breast cancer is safe and does not increase the risk of recurrence, even in patients with hormone receptor–positive disease. However, very limited data are available to counsel women with germline BRCA mutations in that regard. Approximately 12% of breast cancers that arise in women younger than 40 years are related to germline deleterious mutations in BRCA1 and/or BRCA2 genes.

To investigate the impact of pregnancy on breast cancer outcomes in women with germline BRCA mutations, the authors conducted an international, multicentre, hospital-based, retrospective cohort study. Eligible were the women younger than 40 years who harboured deleterious germline BRCA mutations and have been diagnosed with early breast cancer between January 2000 and December 2012.

Primary endpoints were pregnancy rate, and disease-free survival (DFS) between women with and without a pregnancy after breast cancer. Pregnancy outcomes and overall survival (OS) were secondary endpoints.

Of 1,252 women with germline BRCA mutations from whom 811 with BRCA1, 430 with BRCA2, and 11 with BRCA1/2, 195 women had at least 1 pregnancy after breast cancer; pregnancy rate at 10 years was 19% (95% confidence interval [CI], 17% to 22%).

Induced abortions occurred in 16 women (8.2%) and miscarriages in 20 women (10.3%), respectively.

Among 150 women who gave a birth (76.9%) of 170 babies in total, pregnancy complications occurred in 13 (11.6%) and congenital anomalies in 2 (1.8%) cases.  

Median follow-up from breast cancer diagnosis was 8.3 years. No differences in DFS (adjusted hazard ratio [HR], 0.87; 95% CI, 0.61 to 1.23; p = 0.41) or OS (adjusted HR, 0.88; 95% CI, 0.50 to 1.56; p = 0.66) were observed between the pregnancy and non-pregnancy cohorts.

The authors concluded that their findings provide reassuring evidence that pregnancy after early breast cancer in women with BRCA mutations is safe without worsening of maternal prognosis in terms of DFS and OS. The study team observed favourable foetal outcomes.

The study was supported by partial funding from the “Les Amis de l’Institut Bordet” foundation, the Italian Association for Cancer Research (AIRC) and the IRCCS Ospedale Policlinico San Martino (Genoa, Italy) 5×1000 grant.

Reference

Lambertini M, Ameye L, Hamy A-S, et al. Pregnancy After Breast Cancer in Patients With Germline BRCA Mutations. JCO; Published online 16 July 2020. DOI: 10.1200/JCO.19.02399. 

Source

NEWSLETTER

Συμπληρώστε το email σας για να λαμβάνετε τις σημαντικότερες ειδήσεις από το ogkologos.com

Βρείτε μας

2,449ΥποστηρικτέςΚάντε Like
57ΑκόλουθοιΑκολουθήστε

Διαβαστε Επίσης

Καρκίνος και Κορωνοϊός (COVID-19) ΜΕΡΟΣ Α

Εάν είστε καρκινοπαθής, το ανοσοποιητικό σας σύστημα μπορεί να μην είναι τόσο ισχυρό όσο κανονικά, έτσι μπορεί να ανησυχείτε για τους κινδύνους που σχετίζονται...

ΠΑΓΚΟΣΜΙΑ ΗΜΕΡΑ ΚΑΡΚΙΝΟΥ

Η Παγκόσμια Ημέρα Κατά του Καρκίνου καθιερώθηκε με πρωτοβουλία της Διεθνούς Ένωσης κατά του Καρκίνου (UICC), που εκπροσωπεί 800 οργανώσεις σε 155 χώρες του...

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ)

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ) Γράφει ο Δρ Παπαδούρης Σάββας, Παθόλογος-Ογκολόγος   Ο ΜΜΚΠ βρίσκεται αναλογικά στο 80% και πλέον του συνολικού...

Διατρέχουν όντως οι καρκινοπαθείς μεγαλύτερο κίνδυνο λόγω κοροναϊού;

Σε πρακτικό επίπεδο, τα δεδομένα των σχετικών μελετών υποδηλώνουν ότι η χημειοθεραπεία ή οι άλλες αντι-νεοπλασματικές θεραπείες δεν αυξάνουν σημαντικά τον κίνδυνο θνησιμότητας από...

FDA: Η ακτινοβολία των smartphones δεν προκαλεί καρκίνο

Σε μια νέα έκθεσή της, η Υπηρεσία Τροφίμων και Φαρμάκων (FDA) των ΗΠΑ αναφέρει ότι επανεξέτασε τις σχετικές επιστημονικές έρευνες που δημοσιεύθηκαν τα τελευταία...

Νέα ανακάλυψη, νέα ελπίδα για τον καρκίνο

Ένα νεοανακαλυφθέν τμήμα του ανοσοποιητικού μας συστήματος θα μπορούσε να αξιοποιηθεί για την αντιμετώπιση όλων των ειδών καρκίνου, σύμφωνα με επιστήμονες του πανεπιστημίου Cardiff...
- Advertisment -

Ροή Ειδήσεων

Foodie Friday: It’s Berry Season!

July is National Berry Month! If berries aren’t part of your daily diet, now is the perfect time to start eating more of these...

No Link Between Viral Vector in Zynteglo and Acute Myeloid Leukaemia

On 23 July 2021, the European Medicines Agency (EMA) announced that its Committee for Medicinal Products for Human Use (CHMP) has endorsed findings of...

Expecting Mom Finds Pregnant Stray Cat And Gives Her A Home

A woman was 9 months pregnant when she found a pregnant stray cat. Unable to bear the thought of the fellow mom giving birth...

3 Questions Cancer Caregivers Can Ask Themselves to Help Prevent Burnout

Karen Warner Schueler is the president of her own executive coaching firm and author of The Sudden Caregiver: A Roadmap for Resilient Caregiving. For...

FDA Approval of Rylaze Will Address Drug Shortage for Childhood ALL

July 29, 2021, by NCI Staff FDA's approval of Rylaze is expected to help address a long-running shortage of the drug Erwinia asparaginase for kids...

EMA Recommends Granting a Marketing Authorisation for the Hybrid Medicine Imatinib

On 22 July 2021, the European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the granting...