Αρχική World News Larger NGS Gene Panel Linked to More Clinical Utility

Larger NGS Gene Panel Linked to More Clinical Utility

Comparison of two next-generation sequencing (NGS) panels showed that the larger number of actionable gene sites contained in the FoundationOne Panel® (Panel 315) provided increased actionability by targeted therapies information across several tumour types that may aid in guiding clinicians, investigators reported in a poster presented at the MAP 2020 Virtual Congress.

According to Berna Özdemir, Oncology, CHUV – Centre Hospitalier Universitaire Vaudois in Lausanne, Switzerland, currently there are no data to guide the selection of NGS gene panels for clinicians, which prompted Dr Özdemir and colleagues to evaluate NGS gene panels. The investigators compared two commercially available NGS gene panels of different size for clinical utility by quantifying the number of detectable actionable alterations in various solid tumour types identified in a systematic review of the literature.

The investigators evaluated the Ion AmpliSeq Cancer Hotspot Panel® (Panel 50), which covers the hotspots of in 50 genes and the FoundationOne Panel® (Panel 315) covering the complete exons of 315 genes.

The targeted therapies included FDA approved drugs as well as experimental agents

The investigators were able to classify 86% of the genes in the Panel 50 versus 50.3% of the genes in the Panel 315 as clinically actionable.

They matched targeted therapies that could be proposed based on the results from the Panel 50 or Panel 315 using 145 compounds; of these, 99 had received the US Food and Drug Administration (FDA) approval, 14 had been tested in active phase I/II trials, 21 in phase II trails, one compound in a phase II/III trial, and 10 agents had been evaluated in phase III clinical trials. They were respectively categorised as FDA-approved drugs with on-label or off-label use, and as experimental molecules. Putative targeted therapies using the Panel 50 and Panel 315 were identified for 42% versus 18.9% for FDA on-label drugs, 10% versus 6.9% of FDA off-label drugs, and 34.0% versus 24.3% for experimental molecules, with the respective panels.

Across tumour types, the Panel 50 consistently matched more actionable sites to existing agents

Regarding solid tumours, the number of actionable alterations across diverse tumour types was a median 50% higher using the Panel 315 compared to the Panel 50 (T-test, p = 1.72 x 10-5).

This gain was possibly due to Panel 315 containing a higher number of genes involved with homologous recombination repair deficiency that could be targeted by PARP inhibitors (21 genes versus one gene in Panel 50) and also containing 8 genes associated with microsatellite instability compared to one gene in Panel 50 that, therefore, could be targeted by immune checkpoint inhibitors.

Specifically, in lung tumours, with Panel 50 actionability was 29.8% compared to 54.4% with Panel 315, thus a 45.2% increase in actionability was provided by Panel 315.

Across other tumour types, the increase in actionability with the Panel 315 was 50% in glioblastoma, 37.0% in melanoma, 45.0% in sarcoma, and 48.4% in head and neck squamous cell carcinoma. An increase in actionability with the Panel 315 was also observed for ovarian (50%), prostate (60%), cervical (72%), pancreatic (61.1%), colorectal, (43.5%), gastric (55.6%), and breast (50.0%) cancers.

Conclusions

Based on these findings, the authors found that the larger gene panel provided a substantial gain in actionability with either FDA approved or experimental drugs. They attribute this gain to Panel 315 containing a higher number of genes related to homologous recombination repair deficiency that could be targeted by PARP inhibitors and also containing 8 genes associated with microsatellite instability that could be targeted by immune checkpoint inhibitors.

No external funding was disclosed.

Reference

7P – Özdemir B, M. Charrier, C.L. Gerard, et al. Comparison of the clinical utility of two different size next generation sequencing (NGS) gene panels for solid tumours. MAP 2020 Virtual Congress (9-10 October 2020).

Source

NEWSLETTER

Συμπληρώστε το email σας για να λαμβάνετε τις σημαντικότερες ειδήσεις από το ogkologos.com

Βρείτε μας

2,449ΥποστηρικτέςΚάντε Like
57ΑκόλουθοιΑκολουθήστε

Διαβαστε Επίσης

Καρκίνος και Κορωνοϊός (COVID-19) ΜΕΡΟΣ Α

Εάν είστε καρκινοπαθής, το ανοσοποιητικό σας σύστημα μπορεί να μην είναι τόσο ισχυρό όσο κανονικά, έτσι μπορεί να ανησυχείτε για τους κινδύνους που σχετίζονται...

ΠΑΓΚΟΣΜΙΑ ΗΜΕΡΑ ΚΑΡΚΙΝΟΥ

Η Παγκόσμια Ημέρα Κατά του Καρκίνου καθιερώθηκε με πρωτοβουλία της Διεθνούς Ένωσης κατά του Καρκίνου (UICC), που εκπροσωπεί 800 οργανώσεις σε 155 χώρες του...

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ)

ΕΞΕΛΙΞΕΙΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΜΗ-ΜΙΚΡΟΚΥΤΤΑΡΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΠΝΕΥΜΟΝΑ (ΜΜΚΠ) Γράφει ο Δρ Παπαδούρης Σάββας, Παθόλογος-Ογκολόγος   Ο ΜΜΚΠ βρίσκεται αναλογικά στο 80% και πλέον του συνολικού...

Διατρέχουν όντως οι καρκινοπαθείς μεγαλύτερο κίνδυνο λόγω κοροναϊού;

Σε πρακτικό επίπεδο, τα δεδομένα των σχετικών μελετών υποδηλώνουν ότι η χημειοθεραπεία ή οι άλλες αντι-νεοπλασματικές θεραπείες δεν αυξάνουν σημαντικά τον κίνδυνο θνησιμότητας από...

FDA: Η ακτινοβολία των smartphones δεν προκαλεί καρκίνο

Σε μια νέα έκθεσή της, η Υπηρεσία Τροφίμων και Φαρμάκων (FDA) των ΗΠΑ αναφέρει ότι επανεξέτασε τις σχετικές επιστημονικές έρευνες που δημοσιεύθηκαν τα τελευταία...

Νέα ανακάλυψη, νέα ελπίδα για τον καρκίνο

Ένα νεοανακαλυφθέν τμήμα του ανοσοποιητικού μας συστήματος θα μπορούσε να αξιοποιηθεί για την αντιμετώπιση όλων των ειδών καρκίνου, σύμφωνα με επιστήμονες του πανεπιστημίου Cardiff...
- Advertisment -

Ροή Ειδήσεων

Overall Breast Cancer Incidence Down Since 1999, Rates Increase for Women Under 40

U.S. breast cancer death rates decreased by about 1% per year between 2013 and 2018. What were the new case rates during that same...

Impressive Responses to PD-1 Blockade in a Large Cohort of Children and Young Adults with Recurrent/Progressive Germline DNA Replication Repair-Deficient Cancers

A large, observational, registry-based study that leveraged systematically collected data gathered both retrospectively and prospectively through the International Replication Repair Deficiency Consortium reveals impressive...

2-Year-Boy Is So Excited To See Himself In Disney’s ‘Encanto’

The importance of representation in media has been a growing topic of concern, and companies have responded by adding more diversity to their characters,...

Man Walks Entire Continent To Spread Awareness About Mental Health & Suicide Prevention

Matthew Fennell is walking over 3,000 miles across Australia for an important cause and one that is near and dear to his heart. Last year,...

Boy Battling Cancer Becomes Honorary Police Officer, Sworn In To 45 Agencies

At just ten years old, Devarjaye “DJ” Daniel has already been through more than most people go through in their entire lives. DJ has been...

Paclitaxel and Carboplatin Not Inferior When Compared with Paclitaxel and Ifosfamide for the Treatment of Patients with Uterine Carcinosarcoma

With regard to overall survival (OS), paclitaxel and carboplatin was not inferior and demonstrated improved progression-free survival (PFS) when compared with paclitaxel and ifosfamide...