{"id":3058,"date":"2018-12-19T17:00:00","date_gmt":"2018-12-19T17:00:00","guid":{"rendered":"https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2018\/breast-cancer-radiation-therapy-whole-partial-recurrence"},"modified":"2024-11-03T15:17:32","modified_gmt":"2024-11-03T15:17:32","slug":"whole-and-partial-breast-radiation-effective-at-preventing-breast-cancer-from-returning","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/whole-and-partial-breast-radiation-effective-at-preventing-breast-cancer-from-returning\/","title":{"rendered":"Whole- and Partial-Breast Radiation Effective at Preventing Breast Cancer from Returning"},"content":{"rendered":"
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December 19, 2018, by NCI Staff<\/p>\n

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Two large clinical trials compared whole-breast radiation therapy versus partial-breast radiation therapy in some women with early-stage breast cancer.<\/span><\/p>\n

Credit: Lancet Oncology Sept. 2017. doi: 10.1016\/S0140-6736(17)31145-5 CC BY 4.0<\/p>\n<\/div>\n<\/figcaption><\/figure>\n

New results from two clinical trials suggest that either of two types of radiation therapy<\/a> after breast-conserving surgery<\/a> for women with early-stage breast cancer can reduce the risk of the cancer returning.<\/p>\n

In the randomized clinical trials, both whole-breast irradiation (WBI) and accelerated partial-breast irradiation<\/a> (APBI) were associated with low rates of the cancer recurring in the breast where the disease originally developed. The median<\/a> follow-up ranged from more than 5 years to more than 10 years.<\/p>\n

US and Canadian researchers presented results from both trials at the San Antonio Breast Cancer Symposium on December 6.<\/p>\n

WBI is typically given to the whole breast in a series of treatments 5 days a week for 4 to 6 weeks. By comparison, APBI is given only to the part of the breast that has or had cancer in it, and the treatments are completed in a week or less.<\/p>\n

A Head-to-Head Comparison<\/h2>\n

Previous studies have shown that after a diagnosis of early-stage breast cancer, a lumpectomy<\/a> followed by WBI decreases the risk of the cancer recurring<\/a> in the same breast. But many women do not receive the recommended radiation therapy for various reasons, including the inconvenience of traveling to a distant treatment center.<\/p>\n

By delivering larger individual doses of radiation across fewer treatment sessions, APBI has emerged as an alternative approach to WBI. Studies have shown that by treating the area of the breast in the vicinity of the original tumor, APBI can reduce recurrences<\/a>.<\/p>\n

The new trials provide head-to-head comparisons of the two approaches with long-term follow up.<\/p>\n

In the US study<\/a>, for instance, more than 95% of participants in each treatment group\u2014those receiving either WBI or APBI\u2014did not have a recurrence at a median follow-up of 10 years after their treatments ended. Investigators with the Canadian RAPID trial<\/a> reported similar results, although the median follow-up was shorter.<\/p>\n

\u201cIn both studies\u2014and in both treatment arms\u2014the outcomes overall were extremely good,\u201d said Larissa Korde, M.D., of NCI\u2019s Cancer Therapy Evaluation Program<\/a>. Patients with early-stage breast cancer, she continued, \u201ccan use this information to decide whether APBI is the right course for them individually.\u201d<\/p>\n

Following Patients for More than a Decade<\/h2>\n

The NCI-supported National Surgical Adjuvant Breast and Bowel Project (NSABP), now part of NRG Oncology, led the US phase 3 trial. NSABP researchers randomly assigned 4,216 patients with breast cancer who had recently received a lumpectomy to treatment with APBI or WBI.<\/p>\n

Of this group, 25% had ductal carcinoma in situ<\/a> (DCIS), 65% had stage 1 breast cancer, and 10% had stage 2 breast cancer. Eighty-one percent of the patients had hormone receptor<\/a>\u2013positive cancer, and 61% of the patients were postmenopausal.<\/p>\n

Women assigned to APBI received either brachytherapy<\/a> (an internal form of radiation therapy) or three-dimensional conformal external beam radiation therapy<\/a> (3D-CRT)<\/p>\n

After a median follow-up of 10.2 years, 161 patients had a breast cancer recurrence: 90 patients who received APBI and 71 who received WBI. There were modest differences between the groups in terms of side effects.<\/p>\n

\u201cAn Acceptable Choice for Many Women\u201d<\/h2>\n

The two methods of radiation therapy produced similar, if not statistically equivalent, results, noted Frank Vicini, M.D., of 21st Century Oncology of Michigan, who presented the findings of the US study in San Antonio. \u201cThe less burdensome radiation method of APBI may be an acceptable choice for many women,\u201d he added. \u00a0<\/p>\n

Dr. Vicini said that although APBI produced \u201cgood results for a large population of women and does remain a good option,\u201d the study results also suggested that there are \u201climits to the extent that we can cut back\u201d on the schedule and dose of radiation for certain patients and still achieve good outcomes. \u00a0<\/p>\n

More research is needed to develop tools such as biomarkers<\/a> that could help predict which patients with early-stage breast cancer might benefit most from WBI or APBI, according to Dr. Korde.<\/p>\n

RAPID Results<\/h2>\n

In the RAPID study, 2,135 patients from Canada, Australia, and New Zealand were randomly assigned to receive WBI or APBI. Of this group, 82% of patients had invasive breast cancer<\/a> and 18% had DCIS only. The median follow-up was 8.6 years.<\/p>\n

Both treatment groups had low rates of tumor recurrence: In the APBI group, the 5-year and 8-year cumulative rates of recurrence were 2.3% and 3.0%, respectively, whereas the corresponding rates for the WBI group were 1.7% and 2.8%, respectively.\u00a0<\/p>\n

Although there were fewer side effects in patients receiving the APBI regimen compared with the WBI regimen after treatment, there was an increase in side effects associated with the APBI regimen after 3 months, the researchers reported.<\/p>\n

Dr. Korde noted that both trials have collected data on the toxic side effects and the effects on physical appearance associated with each type of radiation therapy.<\/p>\n

\u201cIt will be helpful to have more data that can be used to better understand which patients have a low risk of toxicity with any type of radiation therapy, and therefore which patients might feel more comfortable with using the shorter course of APBI,\u201d said Dr. Korde.<\/p>\n

In the future, she continued, \u201cadditional information on toxicity from the NSABP trial will further add to this important discussion.\u201d<\/p>\n

Source<\/a><\/p>","protected":false},"excerpt":{"rendered":"

December 19, 2018, by NCI Staff Two large clinical trials compared whole-breast radiation therapy versus partial-breast radiation therapy in some women with early-stage breast cancer. Credit: Lancet Oncology Sept. 2017. doi: 10.1016\/S0140-6736(17)31145-5 CC BY 4.0 New results from two clinical trials suggest that either of two types of radiation therapy after breast-conserving surgery for women […]<\/p>\n","protected":false},"author":2,"featured_media":3059,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-3058","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/3058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=3058"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/3058\/revisions"}],"predecessor-version":[{"id":44572,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/3058\/revisions\/44572"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media\/3059"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=3058"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=3058"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=3058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}