{"id":30063,"date":"2023-05-22T06:00:57","date_gmt":"2023-05-22T06:00:57","guid":{"rendered":"https:\/\/news.cancerresearchuk.org\/?p=25678"},"modified":"2024-11-03T15:12:46","modified_gmt":"2024-11-03T15:12:46","slug":"stopping-neuropathy-one-of-chemotherapys-most-challenging-side-effects","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/stopping-neuropathy-one-of-chemotherapys-most-challenging-side-effects\/","title":{"rendered":"Stopping neuropathy: One of chemotherapy\u2019s most challenging side effects"},"content":{"rendered":"
\"AndreAndrea\u2019s treatment had to change because of chemotherapy-induced neuropathy.<\/p>

” data-medium-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Andrea-less-zoom-300×168.jpg” data-large-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Andrea-less-zoom.jpg”><\/p>

Andrea’s treatment had to change because of chemotherapy-induced neuropathy.<\/p><\/div>

A few summers ago, Andrea lost a flip-flop. <\/span> <\/span><\/p>\n

Anyone can misplace a shoe. But this was the only thing between Andrea\u2019s foot and the London pavement. She didn\u2019t notice that it was gone. <\/span> <\/span><\/p>\n

She began dropping things then, too.<\/span> <\/span><\/p>\n

\u201cI couldn\u2019t feel the pressure that I was applying when I was holding drinks. Quite often, they would just slip through my hands.\u201d<\/span> <\/span><\/p>\n

As they smashed and shattered on the floor, glasses didn\u2019t feel like the only things Andrea was struggling to keep hold of.<\/span> <\/span><\/p>\n

She was a young mother with bowel cancer, grappling with her mortality while trying to do her daughter\u2019s hair. And these symptoms weren\u2019t caused by the disease. The thing taking her body away from her was the treatment.<\/span> <\/span><\/p>\n

\u201cWhen you\u2019re going through a cancer diagnosis, trying to be strong for your children and trying not to worry your family, just something as simple as breaking a glass, for the third time in a week, becomes so overwhelming,\u201d Andrea says. <\/span> <\/span><\/p>\n

\u201cI would very often just burst into tears. And someone looking in would probably think, \u2018Why\u2019s she overreacting?\u2019 But it\u2019s because it\u2019s just another thing \u2013 and it has nothing to do with the cancer. What\u2019s trying to save my life is causing me its own set of problems. It\u2019s making my life worse.\u201d<\/span> <\/span><\/p>\n

What was happening?<\/h2>\n

The problem Andrea was \u2013 and, to some extent, still is \u2013 dealing with is a type of nerve damage called <\/span>chemotherapy-induced peripheral <\/span>neuropathy<\/span><\/a> (CIPN, or neuropathy from chemo). <\/span> <\/span><\/p>\n

The symptoms of neuropathy can range from mild pins and needles to losing all feeling and control of your hands and feet. It can be caused by cancer treatment, but doctors don\u2019t have a way to treat it.<\/span> <\/span><\/p>\n

We\u2019re helping some of the world\u2019s best scientists change that. <\/span> <\/span><\/p>\n

Why might chemotherapy cause pins and needles?<\/h2>\n

Chemotherapies<\/span><\/a> are especially good at killing cancer cells, but they can also harm healthy ones. These include the peripheral nerve cells that carry messages back and forth between the brain and spinal cord (the central nervous system) and the rest of the body. When peripheral nerve cells are damaged, it becomes harder for the messages to get through.<\/span><\/p>\n

Blue Ring Media\/Shutterstock.com<\/p>

” data-image-caption=”<\/p>

A damaged peripheral nerve cell (foreground) compared to a healthy one.<\/p>

” data-medium-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/nerve-damage.jpg” data-large-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/nerve-damage.jpg” decoding=”async” class=”wp-image-25702 size-full” src=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/nerve-damage.jpg” alt=”An illustration showing a damaged peripheral nerve compared to a healthy one.” width=”250″ height=”250″ srcset=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/nerve-damage.jpg 250w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/nerve-damage-150×150.jpg 150w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/nerve-damage-96×96.jpg 96w” sizes=”(max-width: 250px) 100vw, 250px”><\/p>

A damaged peripheral nerve cell (foreground) compared to a healthy one. Blue Ring Media\/Shutterstock.com <\/span><\/p>\n<\/div>\n

That\u2019s a big problem when messages have to travel a long way, like to the hands or lower legs. <\/span><\/p>\n

Andrea\u2019s peripheral neuropathy started as pins and needles on the soles of her feet. Then the feeling moved up to her hands.<\/p>\n

\u201cYou know if you sleep on your arm and it goes a bit tingly? I thought that\u2019s what had happened. But it progressively got worse until it was really overwhelming. It\u2019s not something you can ignore. When I\u2019m sleeping, when I\u2019m walking, when I\u2019m sitting down \u2013 constant pins and needles.\u201d<\/span> <\/span><\/p>\n

Then, despite the hot summer, Andrea\u2019s feet became freezing cold. Eventually, she began to lose all sense of them at all.<\/span><\/p>\n

It\u2019s hard to walk when you don\u2019t know where your feet are, so Andrea had to drive everywhere. That\u2019s not much easier. If they weren\u2019t strapped into heavy winter boots, the things on the end of her legs wouldn\u2019t stay on the pedals.<\/span> <\/span><\/p>\n

After her eighth cycle of chemotherapy, Andrea\u2019s doctors had to stop giving her the platinum-based drug <\/span>oxaliplatin<\/span><\/a>. Although it was helping to shrink Andrea\u2019s cancer, oxaliplatin is one of the drugs most likely to cause peripheral neuropathy. It was putting her at risk of permanent, life-altering nerve damage, so her last four cycles of treatment couldn\u2019t include it.<\/span> <\/span><\/p>\n

Why is chemotherapy-induced peripheral neuropathy such a problem?<\/h2>\n

Andrea is now cancer-free. <\/span> <\/span><\/p>\n

In some cases, though, when side-effects stop cancer treatment, they shorten people\u2019s lives. <\/span> <\/span><\/p>\n

Professor Alison Lloyd. Her work on the blood-nerve barrier was funded by us and the Medical Research Council.<\/p>

” data-medium-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Alison-Lloyd-profile.jpg” data-large-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Alison-Lloyd-profile.jpg” decoding=”async” loading=”lazy” class=”wp-image-25694 size-full” src=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Alison-Lloyd-profile.jpg” alt=”Alison Lloyd” width=”250″ height=”250″ srcset=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Alison-Lloyd-profile.jpg 250w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Alison-Lloyd-profile-150×150.jpg 150w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Alison-Lloyd-profile-96×96.jpg 96w” sizes=”(max-width: 250px) 100vw, 250px”><\/p>

Alison Lloyd, whose work is funded by us and the Medical Research Council.<\/p>\n<\/div>\n

As <\/span>Professor Alison Lloyd<\/span><\/a>, from University College London, makes clear, \u201cNeuropathy is one of the major limiting factors for chemotherapy.\u201d That\u2019s because, once a chemotherapy drug starts causing neuropathy, the only way doctors can stop it getting worse is by taking the drug away. <\/span><\/p>\n

The problem is made worse by the fact we can\u2019t even test people to see who\u2019s at risk of developing neuropathy from chemo. All doctors and patients can do is wait to see if symptoms will appear. Uncertainty like that can make treatment decisions much more difficult.<\/span> <\/span><\/p>\n

\u201cWe don\u2019t have an identifiable biomarker, or sign in the body to predict which patients will suffer this toxicity and how severe it will get,\u201d says Professor Lillian Siu, who\u2019s been treating head and neck cancers, often with drugs that can cause neuropathy, for 25 years. \u201cI can\u2019t give more information than \u2018You have to take it and see what happens\u2019. And that\u2019s not necessarily attractive to anybody.\u201d<\/span> <\/span><\/p>\n

To make things better, we need to find out more about how chemotherapy drugs affect nerve cells. That\u2019s Lloyd\u2019s specialism. Her investigations have brought an almost unknown system in our bodies into the spotlight. They could give doctors a way to predict, treat and even prevent neuropathy from chemo.<\/span> <\/span><\/p>\n

The blood, the brain and the nerves<\/h2>\n

We already knew a lot about how the nerve cells in the brain and spinal cord interact with chemotherapies. Or, more commonly, how they don\u2019t. A special protective system called the blood-brain barrier (BBB) stops most drugs getting to them. That makes brain tumours hard to treat, but it can protect the brain and central nervous system from toxic side effects. <\/span> <\/span><\/p>\n

Neurotoxicities like brain fog or \u2018chemo brain\u2019, which Andrea has also experienced, are very difficult problems, but they\u2019d be much worse without the BBB. <\/span> <\/span><\/p>\n

Things are a little different in the rest of the body. Exactly how different has long been a mystery. A lot of scientists know a lot of things about the BBB. Lloyd is the rare one who has found something out about its not-so-distant cousin: the blood-nerve barrier. <\/span><\/p>\n

That works similarly to the BBB, stopping substances in the blood getting to sensitive peripheral nerves \u2013 it just gets nowhere near as much attention. <\/span> <\/span><\/p>\n

\u201cWhen we first went to the blood-brain barrier meetings and said, \u2018We\u2019re trying to understand the blood-nerve barrier,\u2019 the response was mostly, \u2018There\u2019s a blood-nerve barrier?\u2019\u201d recalls Lloyd.<\/span> <\/span><\/p>\n

What have we found out about chemotherapy-induced peripheral neuropathy?<\/h2>\n
Drug molecules (red spots) don\u2019t get into peripheral nerves when the blood-nerve barrier is closed. <\/p>

” data-medium-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-closed-square-300×300.jpg” data-large-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-closed-square.jpg” decoding=”async” loading=”lazy” class=”wp-image-25683 size-thumbnail” src=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-closed-square-150×150.jpg” alt=”An image of a peripheral nerve taken by Alison Lloyd’s team. The blood nerve barrier is closed.” width=”150″ height=”150″ srcset=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-closed-square-150×150.jpg 150w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-closed-square.jpg 300w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-closed-square-96×96.jpg 96w” sizes=”(max-width: 150px) 100vw, 150px”><\/p>

Drugs (red spots) don\u2019t get into peripheral nerves when the barrier is closed.<\/p>\n<\/div>\n

The main difference, as Lloyd got used to explaining, is that the blood-nerve barrier is a little less secure. This might help explain how chemotherapy drugs can get through and cause peripheral neuropathy. <\/span> <\/span><\/p>\n

And it might also make the blood-nerve barrier a promising area to study. While everyone else was looking the other way, Lloyd\u2019s team made a breakthrough. They found a way of opening and closing the blood-nerve barrier, simply by activating a signal in one of the types of cells that support it.<\/span> <\/span><\/p>\n

No one\u2019s ever managed to do something similar in the brain. <\/span><\/p>\n

\u201cThere was always this idea that you had to break down these barriers,\u201d explains Lloyd. \u201cBut that would be toxic. We\u2019ve shown you that can help things cross it, just for a short time, which makes side effects less likely.\u201d<\/span><\/p>\n

When Lloyd\u2019s team opened the blood-nerve barrier, it was much easier for drugs (red spots) to get into peripheral nerves.<\/p>

” data-medium-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-open-square-300×300.jpg” data-large-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-open-square.jpg” decoding=”async” loading=”lazy” class=”wp-image-25684 size-thumbnail” src=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-open-square-150×150.jpg” alt=”An image of a peripheral nerve taken by Alison Lloyd’s team. The blood-nerve barrier is open.” width=”150″ height=”150″ srcset=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-open-square-150×150.jpg 150w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-open-square.jpg 300w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/BNB-open-square-96×96.jpg 96w” sizes=”(max-width: 150px) 100vw, 150px”><\/p>

It\u2019s very different when the barrier is open.<\/p>\n<\/div>\n

On the one side, opening the blood-nerve barrier is an important step towards delivering new types of cancer drugs to cancers that start in or spread through the nervous system. Then, quite apart from cancer, it could help treat nerve cell disorders and brain conditions like <\/span>Huntington\u2019s disease<\/span><\/a>. It could even be the foundation for opening the blood-brain barrier and improving how we treat brain tumours.<\/span> <\/span><\/p>\n

At the same time, understanding how to strengthen or close the blood-nerve barrier could help us stop chemotherapy-induced peripheral neuropathy. <\/span> <\/span><\/p>\n

Select the best payday loan services in the USA<\/a><\/p>\n

How doctors deal with peripheral neuropathy<\/h2>\n

Siu knows just how important that could be. Because there aren\u2019t any tests for peripheral neuropathy today, all doctors like her can do is help patients talk about their symptoms. <\/span><\/p>\n

\u201cYou can monitor other issues with scans and blood tests, but you can\u2019t guess what\u2019s happening to the nerve cells in every patient,\u201d explains Siu. \u201cYou have to rely on them to tell you how they feel.<\/span> <\/span><\/p>\n

\u201cWe bring it up every visit. And I try not to wait till the symptoms become obvious, because sometimes there\u2019s a delayed effect. If you wait till you have moderate toxicity to do something, it could be severe by the next treatment cycle.\u201d<\/span> <\/span><\/p>\n

Professor Lillian Siu has been a senior medical oncologist at the Princess Margaret Cancer Centre in Toronto, Canada since 1998.<\/p>

” data-medium-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Lillian-Siu-profile.jpg” data-large-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Lillian-Siu-profile.jpg” decoding=”async” loading=”lazy” class=”wp-image-25695 size-full” src=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Lillian-Siu-profile.jpg” alt=”Professor Lillian Siu” width=”250″ height=”250″ srcset=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Lillian-Siu-profile.jpg 250w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Lillian-Siu-profile-150×150.jpg 150w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Lillian-Siu-profile-96×96.jpg 96w” sizes=”(max-width: 250px) 100vw, 250px”><\/p>

Professor Lillian Siu has been a senior medical oncologist at the Princess Margaret Cancer Centre in Toronto, Canada since 1998.<\/p>\n<\/div>\n

That discussion goes deeper than symptoms, though. Siu has learned that \u2018who\u2019 is just as important as \u2018what\u2019, \u2018where\u2019 and \u2018when\u2019. <\/span> <\/span><\/p>\n

Our hands and feet can root us in the world and connect us to each other. Some people will choose to continue treatment when their symptoms become severe, but others couldn\u2019t imagine life with long-term peripheral neuropathy.<\/span> <\/span><\/p>\n

\u201cI\u2019ve treated a concert pianist, and they\u2019re exquisitely sensitive about their finger movements,\u201d says Siu. \u201cWith someone like that, we may mutually decide not to give a life-saving treatment and use an alternative, or to stop an effective drug early, because it could affect the most important part of their bodies. <\/span> <\/span><\/p>\n

\u201cSometimes you know the best drug to give, but you can\u2019t give it, or you have to stop, because you\u2019ve decided together that it\u2019s too risky.<\/span> <\/span><\/p>\n

\u201cIt\u2019s always such a tough decision. You can have a patient who\u2019s experiencing a treatment response, which seems to be deepened with every cycle, and then all of a sudden you have no choice but to stop. You don\u2019t want to make the wrong decision that will change the longevity of the patient. But, at the same time, I have to tell them that the neuropathy is only going to get worse if I continue.<\/span> <\/span><\/p>\n

\u201cWe can\u2019t reverse time. The only thing we can do is let time heal. It does get better somewhat. But it\u2019s not fast. And it\u2019s not complete.\u201d<\/span> <\/span><\/p>\n

The toxicities challenge<\/h2>\n

As well as being a senior oncologist, clinical trial director and professor of medicine in Toronto, Canada, Siu is also <\/span>one of the newest members of the Cancer Grand Challenges Scientific Committee<\/span><\/a>. <\/span> <\/span><\/p>\n

Cancer Grand Challenges<\/span><\/a>, the global funding initiative we co-founded with the US National Cancer Institute in 2020, brings together research teams from around the world to take on the biggest problems in cancer research. <\/span>Chemotherapy-induced neurotoxicities and neuropathies<\/span><\/a> was one of the <\/span>9 new challenges announced in March this year<\/span><\/a>. <\/span> <\/span><\/p>\n

Platinum chemotherapy drugs like cisplatin can cause peripheral neuropathy.<\/p>

” data-medium-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Cisplatin-crystals.jpg” data-large-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Cisplatin-crystals.jpg” decoding=”async” loading=”lazy” class=”wp-image-25697 size-full” src=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Cisplatin-crystals.jpg” alt=”Crystals of the chemotherapy drug cisplatin.” width=”250″ height=”250″ srcset=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Cisplatin-crystals.jpg 250w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Cisplatin-crystals-150×150.jpg 150w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Cisplatin-crystals-96×96.jpg 96w” sizes=”(max-width: 250px) 100vw, 250px”><\/p>

Platinum chemotherapy drugs like cisplatin can cause peripheral neuropathy. NCI <\/span><\/p>\n<\/div>\n

Teams with the vision and expertise to uncover more about the processes behind issues like chemotherapy-induced peripheral neuropathy \u2013 and, ultimately, to help us understand how to prevent and treat it \u2013 have until 22 June 2023 to apply for funding of up to \u00a320m ($25m).<\/span><\/p>\n

\u201cWe have such great knowledge of so many things, and peripheral neuropathy doesn\u2019t seem to be insurmountable,\u201d says Siu. \u201cIt\u2019s fitting that it\u2019s a Cancer Grand Challenge, because it can be so difficult for patients, and we have the knowledge in this century to overcome it. If it wasn\u2019t already time, it\u2019s time now.<\/span> <\/span><\/p>\n

\u201cWe may not have leveraged enough knowledge from biologists like Alison. We don\u2019t talk about the blood-nerve barrier very much. There are probably insights there that we haven\u2019t taken advantage of.\u201d<\/span> <\/span><\/p>\n

Better treatments without compromises<\/h2>\n

Those insights are piling up. In their <\/span>latest scientific paper<\/span><\/a>, Lloyd\u2019s team covered the ground of decades of studies into the BBB.<\/span> <\/span><\/p>\n

\u201cWe\u2019ve defined the structure and control of the blood-nerve barrier \u2013 all the cell types that are involved, how they interact, how it can be regulated and why it\u2019s a barrier. It took more than 10 years of development, but we\u2019ve got a <\/span>model that enables you to see how a barrier can be opened and closed.\u201d<\/span> <\/span><\/p>\n

From here, scientists can tackle some of the most debilitating side-effects of cancer treatment, making chemotherapy a better option for everyone. We\u2019re ready with the funding they need to make a difference \u2013 and the knowledge of why it\u2019s so important.<\/span> <\/span><\/p>\n

Andrea and her children<\/p>

” data-medium-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Andrea-communion.jpg” data-large-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Andrea-communion.jpg” decoding=”async” loading=”lazy” class=”wp-image-25685 size-full” src=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Andrea-communion.jpg” alt=”Andrea and her children” width=”250″ height=”250″ srcset=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Andrea-communion.jpg 250w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Andrea-communion-150×150.jpg 150w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/05\/Andrea-communion-96×96.jpg 96w” sizes=”(max-width: 250px) 100vw, 250px”><\/p>

Andrea with her children<\/p>\n<\/div>\n

\u201cYou have this kind of love-hate relationship with chemo,\u201d says Andrea. \u201cYou acknowledge that it could save your life, but at the same time it can cause you its own set of problems. I understand and respect that that\u2019s why some people don\u2019t want it \u2013 they\u2019d much rather protect their quality of life.\u201d<\/span><\/p>\n

We\u2019re with Andrea, and everyone else like her, whatever treatment decision they make. Our job is helping tip the balance. Beating cancer means making sure as many people as possible can get the best quality treatment while living their lives the way they choose.<\/span> <\/span><\/p>\n

\u201cIf chemotherapy didn\u2019t have these side effects, it would be welcomed by so many more people,\u201d says Andrea. And the more people we can treat, the more time we can give.<\/span> <\/span><\/p>\n

Tim<\/em><\/p>\n

More on this topic<\/h3>\n<\/p>\n

Source<\/a><\/p><\/div>","protected":false},"excerpt":{"rendered":"

A damaged peripheral nerve cell (foreground) compared to a healthy one. Blue Ring Media\/Shutterstock.com That\u2019s a big problem when messages have to travel a long way, like to the hands or lower legs. Andrea\u2019s peripheral neuropathy started as pins and needles on the soles of her feet. Then the feeling moved up to her hands. […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-30063","post","type-post","status-publish","format-standard","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/30063","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=30063"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/30063\/revisions"}],"predecessor-version":[{"id":35875,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/30063\/revisions\/35875"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=30063"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=30063"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=30063"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}