{"id":28592,"date":"2023-01-20T09:30:26","date_gmt":"2023-01-20T09:30:26","guid":{"rendered":"https:\/\/news.cancerresearchuk.org\/?p=25193"},"modified":"2024-11-03T15:12:53","modified_gmt":"2024-11-03T15:12:53","slug":"chemo-before-surgery-helps-stop-colon-cancer-coming-back","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/chemo-before-surgery-helps-stop-colon-cancer-coming-back\/","title":{"rendered":"Chemo before surgery helps stop colon cancer coming back"},"content":{"rendered":"
\"AA slight change to the way doctors give chemotherapy could help thousands of people with colon cancer.<\/p>

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A slight change to the way doctors give chemotherapy could help thousands of people with colon cancer. \u00a9Patrick Harrison 2019 <\/span><\/p>\n<\/div>\n

\u201cTiming is everything when it comes to treating colon cancer<\/a>,\u201d says Matthew Seymour, Professor of Gastrointestinal Cancer Research at the University of Leeds. <\/span> <\/span><\/p>\n

He knows that\u2019s much more than just a phrase. Seymour helped run the FOxTROT trial, which showed that starting chemotherapy<\/a> just a few weeks earlier can change outcomes for people with colon cancer. Beginning it before surgery, instead of after, significantly cuts the risk of the disease coming back. <\/span> <\/span><\/p>\n

It\u2019s likely that the findings will change how doctors treat colon cancer (which is a type of bowel, or colorectal, cancer) in the NHS and around the world. <\/span> <\/span><\/p>\n

Changing how we treat colon cancer <\/span> <\/span><\/h2>\n

We funded FOxTROT, and it was led by scientists at the University of Birmingham and the University of Leeds. <\/span> <\/span><\/p>\n

They split 1,053 early-stage<\/a> colon cancer patients from across the UK, Denmark and Sweden into two groups. The first group received 6 weeks of chemotherapy before surgery, and then 18 weeks of chemotherapy after. The second group had standard treatment for colon cancer: surgery followed by 24 weeks of chemotherapy.<\/span> <\/span><\/p>\n

\u201cThe standard approach has been to give chemotherapy after surgery to eradicate any cancer cells that might have spread,\u201d explains <\/span>Dr Laura Magill, an Associate Professor at the Birmingham Clinical Trials Unit, and another one of the FOxTROT trial leads. \u201cBut our research shows that giving some of that chemotherapy before surgery increases the chances that all cancer cells will be killed.\u201d<\/span> <\/span><\/p>\n

Starting chemotherapy 6 weeks before surgery lowered the risk of colon cancer returning in the following 2 years by 28%. It also reduced the number of side effects from surgery, so patients were less likely to have problems like an infection, or to need another operation.<\/span><\/p>\n

Saving lives around the world<\/span> <\/span><\/h2>\n

Those results are especially impressive because they don\u2019t rely on expensive new treatments or technologies. It\u2019s quick and easy to start giving people chemotherapy 6 weeks earlier. <\/span> <\/span><\/p>\n

In fact, at least 5,000 people in the UK could benefit from the change every year \u2013 at no extra cost. Worldwide, the researchers behind the trial predict it could be used to treat hundreds of thousands more. <\/span> <\/span><\/p>\n

\u201cIn many parts of the world cancer treatments can be prohibitively expensive,\u201d says lead investigator Dion Morton, Professor of Surgery at the University of Birmingham. \u201cWe wanted to go in the opposite direction, testing a treatment that could be used on the widest possible group of patients. <\/span> <\/span><\/p>\n

\u201cThanks to funding from Cancer Research UK, doctors in countries around the world will now be able to put these findings into clinical practice, saving many thousands of lives.\u201d<\/span> <\/span><\/p>\n

\n
After taking part in the FOxTROT trial, Geoff Hoggard is now back \u201cliving life to the full\u201d.<\/p>

” data-medium-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/01\/Geoff-selfie-crop.jpeg” data-large-file=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/01\/Geoff-selfie-crop.jpeg” decoding=”async” class=”wp-image-25201 size-full” src=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/01\/Geoff-selfie-crop.jpeg” alt=”A selfie taken by Geoff Hoggard” width=”150″ height=”150″ srcset=”https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/01\/Geoff-selfie-crop.jpeg 150w, https:\/\/news.cancerresearchuk.org\/wp-content\/uploads\/2023\/01\/Geoff-selfie-crop-96×96.jpeg 96w” sizes=”(max-width: 150px) 100vw, 150px”><\/p>

After taking part in the FOxTROT trial, Geoff Hoggard is now back \u201cliving life to the full\u201d.<\/p>\n<\/div>\n

Geoff\u2019s story<\/span> <\/span><\/h2>\n

Geoff Hoggard, from Leeds, joined the trial after he was diagnosed with colon cancer in 2016. <\/span> <\/span><\/p>\n

\u201cI had noticed blood in my poo a few times and initially I had felt quite embarrassed about it. But I ended up being diagnosed with colon cancer, which was a massive wake-up call. Doctors saw the cancer very clearly with a colonoscopy and I was told that it needed urgent treatment, which came as a huge shock.<\/span> <\/span><\/p>\n

\u201cI was willing to take any opportunity to get the most effective treatment. The FOxTROT trial felt like the best way to do that, and I was happy to sign up when my consultant offered to put me on it. <\/span> <\/span><\/p>\n

\u201cI got 6 weeks of chemotherapy before surgery and 18 weeks after, which was hard going. Brain fog and severe tiredness took its toll on me. I kept going, thanks to the support of friends, family and my local church, who were a constant source of strength. <\/span> <\/span><\/p>\n

\u201cEventually, it was all worth it. I\u2019ve had no complications since the surgery, and there were no signs of cancer in the months and years after. 6 years on, I\u2019m back living life to the full. <\/span> <\/span><\/p>\n

\u201cI have no regrets at all about taking part in the FOxTROT trial. I hope that many others will live longer, free from cancer, because of the developing science that underpins this new approach and which worked so well in my case.\u201d <\/span> <\/span><\/p>\n<\/div>\n

More colon cancer trials to come<\/span> <\/span><\/h2>\n

We fund trials like FOxTROT to make sure there can be more people like Geoff living life to the full. <\/span> <\/span><\/p>\n

Today, up to 1 in 3 colon cancer patients see their cancer come back after surgery. Magill speaks for all of us when she says: \u201cThat figure is far too high.\u201d<\/span> <\/span><\/p>\n

Now, though, we have a way to quickly start bringing th<\/span>at<\/span> number down, and FOxTROT could also be a platform for even more improvements. <\/span> <\/span><\/p>\n

The scientists are now working on 2 more clinical trials. One will investigate whether older patients can also benefit from chemotherapy before surgery. The other will find out if adding in more chemotherapy drugs before surgery further reduces the chances of colon cancer coming back. <\/span> <\/span><\/p>\n

If FOxTROT-2 and FOxTROT-3 are as successful as the first study, we can expect more changes in how we treat colon cancer. The two new trials could provide the evidence doctors need to give patients more tailored treatments before and after surgery. <\/span> <\/span><\/p>\n

That\u2019s an exciting prospect. We\u2019ve learned that we can make a difference today, without waiting for expensive new drugs \u2013 but that\u2019s not the whole story. Thanks to FOxTROT, we may have found a better way using those drugs once we have them.<\/span><\/span> <\/span><\/p>\n

More on this topic<\/h3>\n<\/p>\n

Source<\/a><\/p>","protected":false},"excerpt":{"rendered":"

After taking part in the FOxTROT trial, Geoff Hoggard is now back \u201cliving life to the full\u201d. Geoff\u2019s story Geoff Hoggard, from Leeds, joined the trial after he was diagnosed with colon cancer in 2016. \u201cI had noticed blood in my poo a few times and initially I had felt quite embarrassed about it. But […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-28592","post","type-post","status-publish","format-standard","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/28592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=28592"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/28592\/revisions"}],"predecessor-version":[{"id":43084,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/28592\/revisions\/43084"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=28592"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=28592"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=28592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}