{"id":27499,"date":"2021-09-30T13:59:11","date_gmt":"2021-09-30T13:59:11","guid":{"rendered":"https:\/\/ogkologos.com\/2021-asco-annual-meeting-research-round-up-advances-in-treating-brain-tumors-esophageal-cancer-and-colorectal-cancer\/"},"modified":"2024-11-03T15:14:28","modified_gmt":"2024-11-03T15:14:28","slug":"2021-asco-annual-meeting-research-round-up-advances-in-treating-brain-tumors-esophageal-cancer-and-colorectal-cancer","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/2021-asco-annual-meeting-research-round-up-advances-in-treating-brain-tumors-esophageal-cancer-and-colorectal-cancer\/","title":{"rendered":"2021 ASCO Annual Meeting Research Round Up: Advances in Treating Brain Tumors, Esophageal Cancer, and Colorectal Cancer"},"content":{"rendered":"<p class=\"paragraph\">In the annual Research Round Up series,&nbsp;Cancer.Net&nbsp;Associate Editors&nbsp;answer the question,&nbsp;<em>\u201cWhat was the most exciting or practice-changing research in your field presented at the 2021 ASCO Annual Meeting?\u201d<\/em>&nbsp;In this episode, 2&nbsp;experts&nbsp;discuss&nbsp;new&nbsp;research&nbsp;from the&nbsp;meeting&nbsp;on brain tumors and gastrointestinal (GI) cancers.<\/p>\n<p class=\"paragraph\">Listen below, and&nbsp;<a href=\"https:\/\/www.cancer.net\/blog\/podcasts\">subscribe to Cancer.Net Podcasts<\/a>&nbsp;wherever you listen to podcasts&nbsp;for new episodes in this series.&nbsp;<\/p>\n<h3 class=\"paragraph\">New research in brain tumors<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cancer.net\/sites\/cancer.net\/files\/rru-lesser.png\" alt=\"Dr. Glenn Lesser\" width=\"100\" height=\"150\"><\/p>\n<p class=\"paragraph\">Dr. Glenn Lesser, the 2021 <a href=\"https:\/\/www.cancer.net\/node\/30141\">Cancer.Net Associate Editor for Central Nervous System Tumors<\/a>, discusses the results from 2 studies about <a href=\"https:\/\/www.cancer.net\/node\/31327\">brain tumors<\/a>. First, he discusses the <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03224767\" target=\"_blank\" rel=\"noopener\">phase 2 Alliance A071601 clinical trial<\/a>, which was evaluating whether treating people with newly diagnosed papillary <a href=\"https:\/\/www.cancer.net\/node\/31315\">craniopharyngioma<\/a> with a <em>BRAF V600E<\/em> genetic mutation using the targeted therapy drugs vemurafenib (Zelboraf) and cobimetinib (Cotellic) helped shrink their tumors. [3:18] Next, Dr. Lesser discusses the long-term results from the <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02209948\" target=\"_blank\" rel=\"noopener\">phase 2 GEINO 14-01 clinical trial<\/a>, which was studying whether prolonging treatment with the chemotherapy drug temozolomide (Temodar) for people with newly diagnosed glioblastoma helped them live longer. [8:40]<\/p>\n<h3 class=\"paragraph\">Advances in treating esophageal and colorectal cancers<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cancer.net\/sites\/cancer.net\/files\/rru-meyerhardt.jpg\" alt=\"Dr. Jeffrey Meyerhardt\" width=\"100\" height=\"150\"><\/p>\n<p class=\"paragraph\">Dr. Jeffrey Meyerhardt, the 2021 <a href=\"https:\/\/www.cancer.net\/node\/30151\">Cancer.Net Associate Editor for GI Cancers<\/a>, discusses the results from 3 studies in this field, including 1 about esophageal cancer and 2 about colorectal cancer. The first study, the <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03143153\" target=\"_blank\" rel=\"noopener\">phase 3 CheckMate 648 clinical trial<\/a>, compared 3 treatments for people with advanced, recurrent, or metastatic <a href=\"https:\/\/www.cancer.net\/node\/18783\">esophageal squamous cell carcinoma<\/a> to see which helped them live longer and slow the cancer\u2019s growth: the immunotherapy nivolumab (Opdivo) with chemotherapy, nivolumab with another immunotherapy called ipilimumab (Yervoy), or chemotherapy alone. [15:31] The next study discussed, the <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03384940\" target=\"_blank\" rel=\"noopener\">phase 2 DESTINY-CRC01 clinical trial<\/a>, studied whether the targeted therapy drug trastuzumab deruxtecan (Enhertu) helped shrink the tumors of people with HER2-expressing metastatic <a href=\"https:\/\/www.cancer.net\/node\/31317\">colorectal cancer<\/a>. [17:06] Finally, Dr. Meyerhardt discusses the <a href=\"https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2021.39.15_suppl.3504\" target=\"_blank\" rel=\"noopener\">FOCUS4-N clinical trial<\/a>, which was seeing whether <a href=\"https:\/\/www.cancer.net\/node\/24520\">maintenance chemotherapy<\/a> helped people with metastatic colorectal cancer live longer compared with active monitoring, which is closely watching a person\u2019s disease for signs of growth before giving more treatment. [19:17]<\/p>\n<p class=\"paragraph\">Disclosure information for this podcast\u2019s speakers can be found in their individual biographies, which are linked to in the paragraphs above.&nbsp;<\/p>\n<p class=\"paragraph\"><strong><em>Was this podcast useful?<\/em><\/strong>&nbsp;<em>Please subscribe, rate, and review Cancer.Net Podcasts&nbsp;wherever you listen to podcasts.&nbsp;This prerecorded podcast can be listened to online or downloaded to your computer. A <a href=\"https:\/\/www.cancer.net\/node\/41808\">transcript<\/a> is also available. For more information, visit the&nbsp;<\/em><a href=\"http:\/\/www.cancer.net\/blog\/podcasts\" target=\"_blank\" rel=\"noopener\"><em>Cancer.Net podcast page<\/em><\/a><em>.<\/em>&nbsp;<\/p>\n<p class=\"paragraph\"><em>Cancer.Net podcasts are edited for length and content.&nbsp;<\/em>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.cancer.net\/blog\/2021-09\/2021-asco-annual-meeting-research-round-advances-treating-brain-tumors-esophageal-cancer-and\">Source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the annual Research Round Up series,&nbsp;Cancer.Net&nbsp;Associate Editors&nbsp;answer the question,&nbsp;\u201cWhat was the most exciting or practice-changing research in your field presented at the 2021 ASCO Annual Meeting?\u201d&nbsp;In this episode, 2&nbsp;experts&nbsp;discuss&nbsp;new&nbsp;research&nbsp;from the&nbsp;meeting&nbsp;on brain tumors and gastrointestinal (GI) cancers. Listen below, and&nbsp;subscribe to Cancer.Net Podcasts&nbsp;wherever you listen to podcasts&nbsp;for new episodes in this series.&nbsp; New research in [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-27499","post","type-post","status-publish","format-standard","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/27499","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=27499"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/27499\/revisions"}],"predecessor-version":[{"id":43587,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/27499\/revisions\/43587"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=27499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=27499"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=27499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}