{"id":27334,"date":"2021-08-09T06:19:00","date_gmt":"2021-08-09T06:19:00","guid":{"rendered":"http:\/\/be4e0969541fe3dd2e3ae6fb8b6e76b6"},"modified":"2024-11-03T15:14:33","modified_gmt":"2024-11-03T15:14:33","slug":"covid-19-vaccination-efficient-in-patients-with-cancer-who-receive-active-anticancer-treatment","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/covid-19-vaccination-efficient-in-patients-with-cancer-who-receive-active-anticancer-treatment\/","title":{"rendered":"COVID-19 Vaccination Efficient in Patients with Cancer Who Receive Active Anticancer Treatment"},"content":{"rendered":"

Prof. Jean-Yves Blay of the Department of Medical Oncology, Centre L\u00e9on B\u00e9rard, Universit\u00e9 Claude B\u00e9rard in Lyon, France and colleagues reported on 2 August 2021 in the Annals of Oncology<\/em> findings from an analysis of the clinical efficacy of COVID-19 vaccination in a series of 1503 patients with cancer under active treatment for cancer. All patients in the series received one or two doses of COVID-19 vaccine in the Centre L\u00e9on B\u00e9rard and the study team observed reduced SARS-CoV-2 infection and death in those who received two doses of COVID-19 vaccine. However, documented COVID-19 and death rate were higher in patients with cancer who received only one dose of COVID-19 vaccine and in patients with haematological malignancies.<\/p>\n

From 4th<\/sup> January to 6th<\/sup> April 2021, 1503 patients with cancer without previously documented SARS-CoV-2 infection were included in the analysis. There was slightly less female patients (n = 735, 48.9%) and median age was 64.8 years (range, 16.7-95.4). Less than 10% of patients refused the COVID-19 vaccination.<\/p>\n

In total, 1127 patients (74.9%) received BNT162b2, 317 patients (21.1%) received mRNA-1273, and 59 patients (4%) received ChAdOx1 vaccine, depending on availability. Of those, 1203 patients (80%) had a solid tumour and 300 patients (20%) had haematological malignancy, including 72 patients with chronic lymphocytic leukaemia. In total, 1081 patients (71.9%) had metastatic disease. In terms of type of anticancer treatment, 1003 patients (66.7%) received cytotoxic chemotherapy, 60 patients (3.9%) received anti-CD20, 245 patients (16.3%) received radiotherapy and 189 patients (12.5%) have been treated by surgery in the last 3 months.<\/p>\n

In total, 1091 patients (72.6 %) received two doses of COVID-19 vaccine, and 412 patients (27.4 %) received only one dose. Median follow-up was 44 days (range, 1-130) for the whole group of 1503 patients. During that period, 24 of the 1503 patients (1.5%) developed COVID-19 symptoms with documented SARS-CoV-2 on RT-PCR; 4 of 1091 patients (0.4%) who received two doses of vaccine versus 20 of 412 patients (5%) who received only one vaccine dose (p < 0.0001). At 21 days after first COVID-19 vaccine dose, these numbers were 4 of 1001 patients (0.4%) versus 5 of 283 patients (1.7%) among those who received two versus one dose of vaccine (p = 0.016). The same differences were observed when mRNA vaccines were selected.<\/p>\n

RT-PCR documented SARS-CoV-2 infection was not correlated with age, co-morbidities (for example diabetes, renal failure, obesity), solid or haematological malignancies.<\/p>\n

In total, 3 of the 24 patients (12.5%) with positive RT-PCR died of COVID-19; of those 2 among 5 patients (40%) with hematological malignancy versus 1 of 19 patients (5%) with solid tumours (p = 0.036). An overall mortality rate was 0.7% and 0.08% in these two groups. The overall survival within 2 months from the date of the first vaccine dose was inferior in patients vaccinated with one dose versus in patients who received two vaccine doses (log rank p=0.015) in the overall population, and also at 21 days analysis (p = 0.032).<\/p>\n

In total, 96 of the 1503 patients (6%) were tested for antispike antibody after vaccination at a median time of 55 days after the first vaccine dose. Of those 96 patients, 61 (63%) had detectable antispike antibody. Among these, 4 of the 8 (50%) patients who presented later a documented SARS-CoV-2 bv RT-PCR had a detectable antispike antibody. Among the 96 tested patients, 4 of the 5 patients (80%) who died had undetectable antispike antibody after vaccination versus 31 of 91 (34%) of the remaining patients (p = 0.038). Two of the 5 patients who died had a RT-PCR documented SARS-CoV-2 infection.<\/p>\n

The authors concluded that according their experience, COVID-19 vaccination is efficient in patients with cancer. Documented COVID-19 was more frequent in patients who received only one dose of vaccine. In this large series, overall death rate in a period of 2 months following the first vaccine dose was significantly higher in patients who received only one dose of COVID-19 vaccine and in patients with haematological malignancies.<\/p>\n

Reference<\/h4>\n

Heudel P, Favier B, Assaad S, et al.<\/em> Reduced SARS-CoV-2 infection and death after two doses of COVID-19 vaccines in a series of 1503 patients<\/a>. Annals of Oncology<\/em>; Published online 2 August 2021. DOI: https:\/\/doi.org\/10.1016\/j.annonc.2021.07.012<\/a><\/p>\n

Source<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Prof. Jean-Yves Blay of the Department of Medical Oncology, Centre L\u00e9on B\u00e9rard, Universit\u00e9 Claude B\u00e9rard in Lyon, France and colleagues reported on 2 August 2021 in the Annals of Oncology findings from an analysis of the clinical efficacy of COVID-19 vaccination in a series of 1503 patients with cancer under active treatment for cancer. All […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-27334","post","type-post","status-publish","format-standard","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/27334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=27334"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/27334\/revisions"}],"predecessor-version":[{"id":43671,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/27334\/revisions\/43671"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=27334"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=27334"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=27334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}