{"id":27260,"date":"2021-07-16T10:58:00","date_gmt":"2021-07-16T10:58:00","guid":{"rendered":"http:\/\/f444cc99dfd2c4d27beaac3429c22eba"},"modified":"2024-11-03T15:14:34","modified_gmt":"2024-11-03T15:14:34","slug":"hypogammaglobulinemia-and-sars-cov-2-viraemia-determine-covid-19-severity-in-patients-with-haematological-malignancies","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/hypogammaglobulinemia-and-sars-cov-2-viraemia-determine-covid-19-severity-in-patients-with-haematological-malignancies\/","title":{"rendered":"Hypogammaglobulinemia and Sars-CoV-2 Viraemia Determine COVID-19 Severity in Patients with Haematological Malignancies"},"content":{"rendered":"

Dr Jean-Marie Michot and colleagues from the Gustave Roussy in Villejuif, France investigated clinical factors associated with higher risk for severe COVID-19 in patients with haematological malignancies. They wrote on 12 July 2021 in the Annals of Oncology<\/em> that the coronavirus infection itself, rather than cytokine storm, lead to severe and lethal COVID-19 in these patients. The study findings suggest that hypogammaglobulinemia and Sars-CoV-2 viraemia are two relevant determinants of COVID-19 severity in this patient population. <\/p>\n

The study team analyzed characteristics of all patients with haematological malignancies admitted to their hospital for COVID-19 from March to November 2020. In total, 51 adult patients with lymphoma, acute leukaemia, myeloma or other types of haematological malignancies were included in the analysis; from those, 24 (47%) had progressed to severe COVID-19. <\/p>\n

Patients who progressed to severe COVID-19 had at hospital admission significantly lower gammaglobulin levels in the serum (p = 0.0312) and tended to have more advanced age (64.7 versus 57.6 years; p = 0.0503). Lymphopenia was not significantly associated with increased risk of developing severe COVID-19. <\/p>\n

By linear logistic regression, hypogammaglobulinemia remained the most significant factor associated with progression to severe COVID-19. The severity of COVID-19 negatively correlated with serum gammaglobulins by the correlation Pearson statistics method (r = -0.43; p = 0.0018). The intensity of viral replication was higher in patients with hypogammaglobulinemia \u2264 6 g\/L (p = 0.0033) and duration of virus carrier status in nasopharyngeal swabs tended to be prolonged in patients with severe COVID-19. <\/p>\n

The study team then retrospectively assessed Sars-CoV-2 viraemia in 21 patients by RT-PCR in whole blood and 10 patients had detectable viraemia (42%) at hospital admission. Viraemia was associated with a relative risk of progression to severe COVID-19 (p = 0.0019) and COVID-19 death (p = 0.0351). Furthermore, viraemia was more often present in patients with haematological malignancy as compared with patients with solid tumours (47.6% versus 18.2%; p = 0.0099). <\/p>\n

The authors stated that in patients with haematological malignancies, spread of the SARS-CoV-2 virus related to humoral immunosuppression, rather than cytokine storm, drives the COVID-19 severity. They commented that corticosteroids or anti-cytokines drugs such as anti-IL-6 receptor therapies may worsen immunosuppression and should be used with caution in humoral immunocompromised patients. Therapeutics supporting immunity against Sars-CoV-2, such as hyperimmune convalescent plasma, deserves to be investigated for immunocompromised patients. <\/p>\n

Reference<\/h4>\n

Michot JM, Hueso T, Ibrahimi N, et al.<\/em> Severe COVID-19 in patients with hematological cancers presenting with viremia<\/a>. Annals of Oncology<\/em>; Published online 12 July 2021. DOI: https:\/\/doi.org\/10.1016\/j.annonc.2021.07.002<\/p>\n

Source<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Dr Jean-Marie Michot and colleagues from the Gustave Roussy in Villejuif, France investigated clinical factors associated with higher risk for severe COVID-19 in patients with haematological malignancies. They wrote on 12 July 2021 in the Annals of Oncology that the coronavirus infection itself, rather than cytokine storm, lead to severe and lethal COVID-19 in these […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-27260","post","type-post","status-publish","format-standard","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/27260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=27260"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/27260\/revisions"}],"predecessor-version":[{"id":45243,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/27260\/revisions\/45243"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=27260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=27260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=27260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}