{"id":26695,"date":"2021-01-18T11:26:00","date_gmt":"2021-01-18T11:26:00","guid":{"rendered":"http:\/\/a3115ec768a5f23f0ef2985e34e401da"},"modified":"2024-11-03T15:15:49","modified_gmt":"2024-11-03T15:15:49","slug":"genie-registry-identifies-cancer-types-enriched-with-krasg12c-somatic-mutations","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/genie-registry-identifies-cancer-types-enriched-with-krasg12c-somatic-mutations\/","title":{"rendered":"GENIE Registry Identifies Cancer Types Enriched with KRASG12C Somatic Mutations"},"content":{"rendered":"

Findings from the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange (GENIE) registry show that KRASG12C<\/sup><\/em> <\/em>somatic mutations are present in non-small cell lung cancer (NSCLC), colorectal cancer, appendiceal and small bowel cancers, and cancers of unknown primary site, with a mutation frequency of 3 to 14%. Among patients with NSCLC and colorectal cancer, female patients harboured significantly more KRAS<\/em>G12C<\/sup> mutations than male patients. Findings are reported on 14 January 2021 in The New England Journal of Medicine<\/em>.<\/p>\n

The GENIE team searched the distribution of KRAS<\/em>G12C<\/sup> mutations in 32,138 patients with 10 cancer types across race and sex. In total, 2045 patients (6.4%) were Asian, 2355 (7.3%) were Black, and 27,738 (86.3%) were White.<\/p>\n

KRAS<\/em>G12C<\/sup> mutations were identified in 1867 samples, most frequently in patients with NSCLC, 1443 of 10,444 (13.8%); 74 of 2105 patients with cancer of unknown primary site (3.5%), 12 of 368 patients with appendiceal cancer (3.3%), 234 of 7402 patients with colorectal cancer (3.2%), and 7 of 223 patients with small-bowel cancer (3.1%).<\/p>\n

Among patients with NSCLC, White and Black patient groups were enriched for KRAS<\/em>G12C<\/sup> mutations more than Asians (White patients 13%, Black patients 10.9%, Asian patients 3.6%; p < 0.001).<\/p>\n

The GENIE researchers found differences by sex within the same ethnic groups of patients with NSCLC. KRAS<\/em>G12C<\/sup> mutations occurred more often in White female patients than in White male patients with NSCLC (odds ratio 1.4; 95% confidence interval [CI] 1.3 to 1.6; Q < 0.001) and more often in Asian male patients than in Asian female patients (odds ratio 5.2; 95% CI 1.9 to 17.9; Q = 0.01).<\/p>\n

Among patients with colorectal cancer, White female patients were enriched for KRAS<\/em>G12C<\/sup> mutations more than White male patients (odds ratio 1.4; 95% CI 1.1 to 1.9; Q = 0.04).<\/p>\n

The authors underlined that their data illustrate differences according to sex and ethnic group in the prevalence of KRAS<\/em>G12C<\/sup> mutations in various cancer types and emphasized the importance of mutation analysis of larger numbers of non-White populations and in rare cancers. With the promising efficacy of sotorasib, recruiting patients with cancer types enriched with KRAS<\/em>G12C<\/sup> somatic mutations in future clinical studies will be important.<\/p>\n

Reference<\/h4>\n

Nassar AH, Adib E, Kwiatkowski DJ. Distribution of KRAS<\/em>G12C Somatic Mutations across Race, Sex, and Cancer Type<\/a>. N Engl J Med<\/em> 2021; 384:185-187.<\/p>\n

Source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Findings from the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange (GENIE) registry show that KRASG12C somatic mutations are present in non-small cell lung cancer (NSCLC), colorectal cancer, appendiceal and small bowel cancers, and cancers of unknown primary site, with a mutation frequency of 3 to 14%. Among patients with NSCLC and colorectal […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-26695","post","type-post","status-publish","format-standard","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/26695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=26695"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/26695\/revisions"}],"predecessor-version":[{"id":43998,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/26695\/revisions\/43998"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=26695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=26695"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=26695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}