{"id":26354,"date":"2020-09-09T12:00:00","date_gmt":"2020-09-09T12:00:00","guid":{"rendered":"https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2020\/pazopanib-votrient-soft-tissue-sarcoma-children-adults"},"modified":"2024-11-03T15:16:19","modified_gmt":"2024-11-03T15:16:19","slug":"pazopanib-shows-promise-for-children-adults-with-soft-tissue-sarcomas","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/pazopanib-shows-promise-for-children-adults-with-soft-tissue-sarcomas\/","title":{"rendered":"Pazopanib Shows Promise for Children, Adults with Soft Tissue Sarcomas"},"content":{"rendered":"

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\"Angiogenesis<\/div>
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Pazopanib is thought to work, in part, by blocking the growth of new blood vessels that support tumor growth.<\/p>\n

Credit: Wikimedia Commons\/Scientific Animations. CC-BY-SA-4.0.<\/p>\n<\/div>\n<\/figcaption><\/figure>\n<\/div>\n

For most people with advanced soft tissue sarcoma, standard treatment includes radiation therapy and possibly chemotherapy before surgery to remove the tumor. The goal is to kill as much of the tumor as possible before operating, which can help the surgeon get all or most of the tumor out safely and kill cancer cells that may have escaped from the original tumor.<\/p>\n

Now, early results of a clinical trial show that for children and adults with advanced soft tissue sarcoma<\/a>, adding the targeted drug pazopanib (Votrient)<\/a> to chemotherapy<\/a> and radiation treatment<\/a> is safe and increases the chances that most of the tumor will be dead before surgery<\/a>.<\/p>\n

Having a mostly dead tumor before surgery also is thought\u2014but not proven\u2014to improve how well patients do in the long term, said a lead investigator on the trial, Aaron Weiss, D.O., of Maine Medical Center in Portland, Maine.<\/p>\n

The new findings, published July 20 in The Lancet Oncology<\/em>, \u201care very promising\u201d though still preliminary, said Christine Heske, M.D., of the Pediatric Oncology Branch<\/a> in NCI\u2019s Center for Cancer Research, who was not involved with the study. \u201cIt will be critical to determine whether these early tumor responses<\/a> translate to survival benefits for these patients.\u201d <\/p>\n

\u201cThis is an important study because it is trying to change the standard of care<\/a> for people with advanced soft tissue sarcoma,\u201d said Breelyn Wilky, M.D., a medical oncologist at the University of Colorado Cancer Center. Dr. Wilky was an investigator for the trial in her previous position, at the University of Miami. <\/p>\n

The NCI-funded clinical trial also was notable because it was designed to include children, adolescents, and adults, which allowed researchers to study a larger group of people than is typical for clinical trials of these rare cancers, Drs. Wilky and Heske said.<\/p>\n

The trial was developed and run jointly by two large clinical trial groups that are part of NCI\u2019s National Clinical Trials Network<\/a>: the Children\u2019s Oncology Group<\/a>, which studies childhood cancers, and NRG Oncology, which studies adult cancers. <\/p>\n

This collaborative approach \u201ccould be a model for studying soft tissue sarcoma and other rare cancers\u201d that affect people across a wide age range, including adolescents and young adults, Dr. Heske said.<\/p>\n

Surgery to Remove Larger Tumors Can Be Risky<\/h2>\n

Soft tissue sarcoma is a group of about 100 different cancer types that form in the soft tissues<\/a> of the body, including muscle, tendons<\/a>, lymph vessels<\/a>, and tissue around joints. The tumors can be found anywhere in the body but often form in the arms, legs, chest, and abdomen.<\/p>\n

These cancers account for fewer than 1% of all new cancer cases diagnosed each year. <\/p>\n

Surgery to remove large, advanced soft tissue sarcomas often is more difficult than surgery to remove a small tumor and can be risky based on the tumor\u2019s location\u2014for example, if the tumor is close to important structures like blood vessels or nerves, Dr. Wilky said.<\/p>\n

Normally, surgeons will aim to remove a tumor completely, along with 1\u20132 centimeters of normal tissue around it, \u201cto make sure they\u2019ve got everything,\u201d she continued. \u201cBut if you can\u2019t [do that safely], the next best thing is to make sure that the edge of the tumor that you leave behind is dead\u2026 and hopefully won\u2019t be able to spread or cause the cancer to come back.\u201d <\/p>\n

The new study involved patients with tumors that were large and more aggressive<\/a> and initially not good candidates for surgery; in some cases, the cancer had spread, or metastasized, from the site of the original tumor.<\/p>\n

Pazopanib, which is taken as a pill, is FDA-approved for use by itself in adults with soft tissue sarcoma who have received chemotherapy. \u201cBut at the time this study was developed, we didn\u2019t know whether it was safe to combine pazopanib with the more traditional therapy used\u201d for either adults or children with these cancers, Dr. Weiss said.<\/p>\n

The study included 81 children and adults with advanced soft tissue sarcoma tumor from 57 hospitals in the United States and Canada. Participants were 2 years old or older, and the median<\/a> age was 19 years in the control group<\/a> and 25 years in the pazopanib group. All patients had the soft tissue sarcoma types that are known to be somewhat responsive to chemotherapy.<\/p>\n

Patients were randomly assigned to receive chemotherapy with doxorubicin<\/a> and ifosfamide<\/a>, a combination commonly used to treat soft tissue sarcoma, along with radiation therapy (control group), or the same chemotherapy and radiation therapy plus pazopanib taken daily.<\/p>\n

Participants underwent surgery 13 weeks after treatment began. A pathologist then examined the removed tumor tissue under a microscope to determine the percentage of tumor cells that were dead after treatment, which is known as the pathological response.<\/p>\n

Enrollment Stopped Early Due to Clear Benefit<\/h2>\n

The trial was designed to compare the percentage of patients in each treatment group that had a pathological near complete response<\/a>, which was defined as at least 90% of the tumor being dead at the time of surgery. <\/p>\n

Although the team had planned to enroll 100 patients, enrollment was stopped early, after it became clear that pazopanib and chemoradiotherapy was more effective than chemoradiotherapy alone. <\/p>\n

Among the 42 patients remaining in the study at the time results were analyzed, 14 of 24 (58%) in the pazopanib group versus 4 of 18 (22%) in the control group had a pathological near complete response. <\/p>\n

One of the most exciting findings of the study, Dr. Wilky said, \u201cis that adding pazopanib to standard chemotherapy was feasible from a safety and side-effect perspective.\u201d <\/p>\n

Serious side effects seen most commonly included low white blood cell counts, a fever requiring hospitalization, and wound complications. These side effects occurred more often in patients receiving pazopanib, and 59% of patients in the pazopanib group had a serious side effect related to the drug.<\/p>\n

Awaiting Long-Term Results <\/h2>\n

The research team plans to follow the remaining patients to find out whether greater pathological response translates into improved long-term outcomes and expects to have those results in about 4 years. <\/p>\n

However, the relatively small number of patients remaining in the study and the fact that the study was not designed to detect whether patients live longer may make it hard to get a clear answer, Dr. Weiss said. <\/p>\n

Another potential limitation, Dr. Heske noted, is that roughly half of all patients in each treatment groups had a single type of soft tissue sarcoma, synovial sarcoma<\/a>, and it\u2019s not clear if all patients in the trial benefited from pazopanib in the same manner. However, she continued, \u201cif you tried to study some of the other types of soft tissue sarcoma on their own, you’d have no opportunity to do a clinical trial because they’re just so rare.\u201d<\/p>\n

One question that remains, which this study did not address, is whether pazopanib would enhance the effects of chemotherapy in types of soft tissue sarcoma not traditionally thought to be responsive to chemotherapy, Dr. Heske said.<\/p>\n

Another key question, which additional work planned as part of the study may help answer, is that \u201cwe still don\u2019t really understand how pazopanib works\u201d in treating soft tissue sarcoma, Dr. Wilky said.<\/p>\n

Although pazopanib is considered a targeted therapy<\/a>, the drug blocks the growth of new blood vessels that feed tumors, affects the way the immune system<\/a> works, and affects the way cancer cells talk to each other, she continued. <\/p>\n

\u201cAnd we\u2019ve never delved in and asked, \u2018What is the important target of pazopanib? What do you need to have in your sarcoma for this drug to be effective?\u2019\u201d she said. \u201cIf we had a better understanding, we would be able to use it in a much more precise way.\u201d<\/p>\n

Source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

September 9, 2020, by NCI Staff Pazopanib is thought to work, in part, by blocking the growth of new blood vessels that support tumor growth. Credit: Wikimedia Commons\/Scientific Animations. CC-BY-SA-4.0. For most people with advanced soft tissue sarcoma, standard treatment includes radiation therapy and possibly chemotherapy before surgery to remove the tumor. The goal is […]<\/p>\n","protected":false},"author":2,"featured_media":26355,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-26354","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/26354","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=26354"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/26354\/revisions"}],"predecessor-version":[{"id":45564,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/26354\/revisions\/45564"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media\/26355"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=26354"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=26354"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=26354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}