{"id":23957,"date":"2020-05-08T17:30:12","date_gmt":"2020-05-08T17:30:12","guid":{"rendered":"http:\/\/cmshub.wpengine.com\/?p=313644"},"modified":"2024-11-03T15:16:48","modified_gmt":"2024-11-03T15:16:48","slug":"some-hormone-therapy-drugs-for-breast-cancer-could-reduce-alzheimers-risk","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/some-hormone-therapy-drugs-for-breast-cancer-could-reduce-alzheimers-risk\/","title":{"rendered":"Some Hormone Therapy Drugs For Breast Cancer Could Reduce Alzheimer\u2019s Risk"},"content":{"rendered":"

Hormone-modulating breast cancer treatments (HMTs) like tamoxifen and aromatase inhibitors (AIs) could reduce a patient\u2019s risk of developing dementia or Alzheimer\u2019s later in life.<\/span>Tamoxifen is a selective estrogen receptor modulator (SERM) that\u2019s often prescribed after<\/strong> surgery or other breast cancer treatment to prevent the cancer from coming back. It is only prescribed for hormone-receptor-positive breast cancer, or to reduce breast cancer risk<\/a> in women who have a high risk of developing the disease but haven\u2019t yet gotten it.<\/span>Like tamoxifen, AIs are also only effective<\/a> against hormone-receptor-positive breast cancers. They block an enzyme called aromatase, which is responsible for turning the hormone androgen into estrogen. By stopping this enzyme and reducing estrogen production, any hormone-fueled cancer cells will find it difficult to grow. AIs can\u2019t stop the ovaries from producing estrogen, so this treatment is primarily used in postmenopausal women.<\/span>Both types of treatment seem to reduce the risk of developing neurodegenerative disease (NDD).<\/span>\u201cThe fact that breast cancer is the second most common cancer in women (after skin cancer) and that women are disproportionately affected by AD [Alzheimer\u2019s disease] and related dementia provides us with an opportunity to reduce the global disease burden of NDDs,\u201d wrote<\/a> the study\u2019s authors.<\/span>
\n<\/span>\"\"<\/span>Photo: Adobe Stock\/mrakorius<\/span>The study<\/a> was published in JAMA Network Open<\/em>. Researchers looked at data from a Humana insurance<\/a> claims database that primarily contained patients who lived in the southeastern United States. They looked at the data of 57,843 breast cancer patients who were at least 45 years old over a period of ten years, from January 1, 2007, to March 31, 2017.<\/span>Of the 57,843 total patients, 18,126 patients (31.3%<\/a>) had undergone HMT, including tamoxifen, raloxifene, nonsteroidal AIs (anastrozole or letrozole), or a steroidal AI (exemestane), and 39,717 patients did not undergo HMT. The HMT group had an average age of 76.2 and the non-HMT group had an average age of 76.8 years.<\/span>
\n<\/span>\"\"<\/span>Photo: Adobe Stock\/fizkes<\/span>Patients who received HMT were significantly less likely<\/a> to be diagnosed with a neurodegenerative disease like dementia. They had a 12.5% chance, while the non-HMT group had a 14.3% chance.<\/span>Researchers found<\/a> that the percentage of those with Alzheimers disease was 4.9% in the HMT group, compared to 6.0% in the non-HMT group. The HMT group also had a lower risk of dementia, with 10.4% being diagnosed with dementia versus 11.8% in the non-HMT group. The mean follow-up time was five and a half years.<\/span>\"\"<\/span>Photo: Adobe Stock\/Photographee.eu<\/span>
\n<\/span>While HMTs like tamoxifen and AIs caused the greatest reductions in NDDs, a SERM called raloxifene did not offer any protection.<\/span>\u201cThe protection associated with the SERMs was exclusively<\/strong> due to tamoxifen and not to raloxifene,\u201d the study\u2019s authors wrote<\/a>. \u201cThis finding might explain why previous studies using SERMs were not found to be effective because raloxifene was the focus of several of these AD trials.\u201d<\/span>As for aromatase inhibitors, all types offered a reduction in the risk for Alzheimer\u2019s and dementia, but exemestane (a steroidal AI) had the strongest reduction when compared to anastrozole or letrozole (which are nonsteroidal).<\/span>\"\"<\/span>Photo: Adobe Stock\/Robert Kneschke<\/span>
\n<\/span>\u201cWith the increased life expectancy seen after treatment, therapy selection for breast cancer should include a careful discussion of the risks and benefits of each treatment option that may be associated with a reduced risk of neurodegenerative disease,\u201d the authors wrote<\/a>.<\/span>Source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Hormone-modulating breast cancer treatments (HMTs) like tamoxifen and aromatase inhibitors (AIs) could reduce a patient\u2019s risk of developing dementia or Alzheimer\u2019s later in life.Tamoxifen is a selective estrogen receptor modulator (SERM) that\u2019s often prescribed after surgery or other breast cancer treatment to prevent the cancer from coming back. It is only prescribed for hormone-receptor-positive breast […]<\/p>\n","protected":false},"author":2,"featured_media":23958,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-23957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/23957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=23957"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/23957\/revisions"}],"predecessor-version":[{"id":44296,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/23957\/revisions\/44296"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media\/23958"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=23957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=23957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=23957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}