{"id":21255,"date":"2020-03-13T16:46:10","date_gmt":"2020-03-13T16:46:10","guid":{"rendered":"http:\/\/cmshub.wpengine.com\/?p=307005"},"modified":"2024-11-03T15:16:49","modified_gmt":"2024-11-03T15:16:49","slug":"the-obesity-paradox-it-increases-diabetes-risk-but-can-help-cancer-patients-respond-to-treatment","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/the-obesity-paradox-it-increases-diabetes-risk-but-can-help-cancer-patients-respond-to-treatment\/","title":{"rendered":"The Obesity Paradox: It Increases Diabetes Risk But Can Help Cancer Patients Respond To Treatment"},"content":{"rendered":"

Being overweight or obese (as defined by having a high BMI, which measures weight relative to height), has been linked to countless health issues: cancer, diabetes, cardiovascular health, high blood pressure, high cholesterol, insulin resistance, and more. As a person\u2019s BMI increases, risk of heart disease, stroke, and type 2 diabetes increase.<\/span>The World Health Organization (WHO) estimates that 2.8 million people die<\/a> every year due to being overweight and obese and the health issues that go along with that.<\/span>However, a group of researchers has found a tiny silver lining: people who are obese or overweight and have cancer seem to respond better to immunotherapy treatment.<\/span>\"\"<\/span>Photo: Adobe Stock\/Rostislav Sedlacek<\/span>
\n<\/span>The study was published in the journal JAMA Oncology<\/em> and led by researchers from Flinders University<\/a> in Australia.<\/span>Atezolizumab is an immunotherapy treatment that\u2019s in clinical trials for non-small-cell lung cancer (NSCLC). Looking at a pool of 1,434 participants who were taking the drug in four different clinical trials<\/a>, researchers at Flinders compared each person\u2019s responsiveness to atezolizumab to their BMI. Nearly half the participants (49%) were normal weight, 34% were overweight, and 7% were obese.<\/span>\"\"<\/span>Photo: Adobe Stock\/Africa Studio<\/span>They found that those with a higher BMI had a higher responsiveness to the drug, and a significant reduction in mortality<\/a>.<\/span>
\n<\/span>\u201cPrevious studies have explored a concept called as \u2018obesity paradox\u2019 where obesity is associated with increased risks for developing certain cancers and, counter-intuitively, may protect and give greater survival benefits in certain individuals,\u201d said<\/a> Ganessan Kichenadasse, a medical oncology researcher at the Flinders Centre for Innovation in Cancer. \u201cOur study provides new evidence to support the hypothesis that high BMI and obesity may be associated with response to immunotherapy.\u201d<\/span>\"\"<\/span>Photo: Adobe Stock\/pressmaster<\/span>Despite the positive results in the study related to high BMI, researchers emphasized that maintaining a healthy weight and lifestyle are crucial to overall health.<\/span>
\n<\/span>\u201cThis is an interesting outcome and it raises the potential to investigate further with other cancers and other anti-cancer drugs,\u201d Kichenadasse said<\/a>. \u201cWe need to do further studies into the possible link between BMI and related inflammation, which might help to understand the mechanisms behind paradoxical response to this form of cancer treatment.\u201d<\/span>Source<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Being overweight or obese (as defined by having a high BMI, which measures weight relative to height), has been linked to countless health issues: cancer, diabetes, cardiovascular health, high blood pressure, high cholesterol, insulin resistance, and more. As a person\u2019s BMI increases, risk of heart disease, stroke, and type 2 diabetes increase.The World Health Organization […]<\/p>\n","protected":false},"author":2,"featured_media":21256,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-21255","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/21255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=21255"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/21255\/revisions"}],"predecessor-version":[{"id":44319,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/21255\/revisions\/44319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media\/21256"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=21255"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=21255"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=21255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}