{"id":19374,"date":"2020-02-04T19:53:51","date_gmt":"2020-02-04T19:53:51","guid":{"rendered":"http:\/\/cmshub.wpengine.com\/?p=300585"},"modified":"2024-11-03T15:16:50","modified_gmt":"2024-11-03T15:16:50","slug":"triple-negative-breast-cancer-may-not-be-categorized-as-breast-cancer-for-long","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/triple-negative-breast-cancer-may-not-be-categorized-as-breast-cancer-for-long\/","title":{"rendered":"Triple Negative Breast Cancer May Not Be Categorized As \u2018Breast\u2019 Cancer For Long"},"content":{"rendered":"

Triple negative breast cancer may not be breast cancer after all, a study out of New York has found.<\/span>Triple negative breast cancer (TNBC) is not fueled by any of the hormones that are typically responsible for breast cancer growth: estrogen, progesterone, and the HER2\/neu gene. Between 10% and 20%<\/a> of breast cancers are TNBC, and it disproportionally affects black women and Hispanic women. Patients with TNBC typically face fewer treatment options, since hormone therapies can\u2019t be used against the cancer.<\/span>But TNBC may be closer to non-breast cancers on a molecular level. Scientists have discovered that two mutated genes are present in the majority of TNBC patients \u2014 and how these genes interact with each other during DNA replication<\/a> seems to spur the growth of cancerous cells.<\/span>This could change not only how the TNBC is classified, but treatment options as well.<\/span>\"\"<\/span>Photo: Adobe Stock\/Christoph Burgstedt<\/span>
\n<\/span>Researchers from The Graduate Center of The City University of New York, Hunter College, Memorial Sloan Kettering Cancer Center, and the University of Chicago published<\/a> their findings in Cancer Research<\/em>, a journal from the American Association of Cancer Research.<\/span>The researchers studied data from The Cancer Genome Atlas about black women who had triple negative breast cancer, analyzing multiple breast cancer cell lines and tissue samples. They found that over 80%<\/a> of the patients they studied had a mutated p53 gene, which is a tumor-suppressor gene, as well as a mutated PARP<\/a> gene, which is responsible for DNA repair and maintenance.<\/span>\"\"<\/span>Photo: Adobe Stock\/vectorfusionart<\/span>
\n<\/span>Researchers then combined two existing drugs, talazoparib and temozolomide, to create a targeted therapy for these mutated genes that could potentially thwart tumor growth. They then tested the drug combination on TNBC samples in the lab \u2014 and they were successful.<\/span>\u201cOur new findings suggest that the presence of both [p53] and PARP could serve as a good identifier of breast cancers that would respond to combined treatment with talazoparib \u2014 a PARP inhibitor that was developed to treat breast cancers with the BRCA mutation \u2014 and temozolomide \u2014 a chemotherapy agent that is used to treat some brain cancers,\u201d said<\/a> Professor Jill Bargonetti, who was involved in the study. \u201cThis is an exciting finding because it could lead to the first targeted therapy for triple negative breast cancer, enabling more precise and effective treatment of a very aggressive form of the disease.\u201d<\/span>\"\"<\/span>Photo: AdobeStock\/JJAVA<\/span>
\n<\/span>More research needs to be done, and the researchers\u2019 next study will be testing the two drugs on tumor samples from animals with TNBC.<\/span>If more studies prove successful using PARP inhibitor therapies on TNBC, it could lead to a reclassification<\/a> of TNBC to a category of cancer called mutant p53\/PARP1 positive cancers.<\/span>Source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Triple negative breast cancer may not be breast cancer after all, a study out of New York has found.Triple negative breast cancer (TNBC) is not fueled by any of the hormones that are typically responsible for breast cancer growth: estrogen, progesterone, and the HER2\/neu gene. Between 10% and 20% of breast cancers are TNBC, and […]<\/p>\n","protected":false},"author":2,"featured_media":19375,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[5137],"tags":[],"class_list":["post-19374","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-world-news"],"_links":{"self":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/19374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/comments?post=19374"}],"version-history":[{"count":1,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/19374\/revisions"}],"predecessor-version":[{"id":44343,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/posts\/19374\/revisions\/44343"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media\/19375"}],"wp:attachment":[{"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/media?parent=19374"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/categories?post=19374"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ogkologos.com\/en\/wp-json\/wp\/v2\/tags?post=19374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}