{"id":13402,"date":"2019-10-08T12:00:00","date_gmt":"2019-10-08T12:00:00","guid":{"rendered":"https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2019\/men-oral-hpv-infection-vaccine-herd-immunity"},"modified":"2024-11-03T15:17:07","modified_gmt":"2024-11-03T15:17:07","slug":"hpv-vaccine-may-provide-men-with-herd-immunity-against-oral-hpv-infections","status":"publish","type":"post","link":"https:\/\/ogkologos.com\/en\/hpv-vaccine-may-provide-men-with-herd-immunity-against-oral-hpv-infections\/","title":{"rendered":"HPV Vaccine May Provide Men with \u201cHerd Immunity\u201d against Oral HPV Infections"},"content":{"rendered":"

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Credit: National Cancer Institute<\/p>\n<\/div>\n<\/figcaption><\/figure>\n<\/div>\n

The potential benefits of vaccines are twofold: In addition to directly protecting those who get the vaccine, they also protect those who don\u2019t. The latter, a phenomenon called herd immunity, occurs only if enough people get vaccinated that the disease-causing germ can\u2019t spread easily.<\/p>\n

Now a new study suggests that the human papillomavirus (HPV) vaccine<\/a> may be providing men with herd immunity against HPV infections of the throat. Oral HPV infections cause over 70% of all\u00a0oropharyngeal cancers<\/a> in the United States, and rates of these cancers in men have skyrocketed over the past several decades.<\/p>\n

Between 2009 and 2016, rates of HPV vaccination in both males and females increased while rates of oral HPV infection among unvaccinated men dropped, the new study showed<\/a>.<\/p>\n

Results of the study, which was led by Anil Chaturvedi, Ph.D., and Barry Graubard, Ph.D., of NCI\u2019s Division of Cancer Epidemiology and Genetics<\/a>, were published September 10 in JAMA<\/em>.<\/p>\n

The findings \u201cadd to accumulating evidence that HPV vaccination prevents oral infection with HPV,\u201d said Gregory Zimet, Ph.D., of Indiana University, who studies HPV vaccine uptake but was not involved in the current study.<\/p>\n

That is \u201creally meaningful,\u201d Dr. Zimet added, because it is difficult to catch oropharyngeal cancers\u00a0at their early, most treatable stages. More than half of oral cancers have already spread to other places in the body by the time they are discovered<\/a>.<\/p>\n

Prevention of oral HPV infections today can prevent oropharyngeal cancers in the future, Dr. Chaturvedi said.<\/p>\n

Oral HPV Infections and Oropharyngeal Cancer<\/h2>\n

More than a decade ago, Dr. Chaturvedi and his colleagues reported that rates of oropharyngeal cancer were climbing rapidly in the United States<\/a>, particularly among young men. The\u00a0cause of this alarming jump turned out to be a rise in oral HPV infections<\/a>. The other major causes of oropharyngeal cancer are smoking and heavy alcohol consumption.<\/p>\n

Subsequent studies showed that oral HPV infections and HPV-related oropharyngeal cancers are three to five times more common in men than women.<\/p>\n

In 2009, Dr. Chaturvedi and his colleagues worked with the Centers for Disease Control and Prevention (CDC) to make oral HPV infections a focus of the National Health and Nutrition Examination Survey (NHANES)<\/a>, an ongoing health study of a representative sample of children and adults in the United States.<\/p>\n

Since then, scientists have used data from NHANES to explore the epidemiology<\/a> of oral HPV infections, including a 2017 study led by Dr. Chaturvedi that provided some preliminary evidence that the HPV vaccine may prevent oral HPV infections<\/a>.<\/p>\n

Investigating Herd Protection<\/h2>\n

Because there is accumulating evidence for herd protection against cervical HPV infections<\/a>, Dr. Chaturvedi and his colleagues wondered whether a similar phenomenon existed for oral HPV infections. To explore that idea, the researchers turned to NHANES data once again. \u00a0<\/p>\n

Between 2009 and 2016, nearly 14,000 men and women ages 18 to 59 participated in NHANES. Participants self-reported whether they had received the HPV vaccine and provided mouth rinse samples that were tested for 37 HPV types.<\/p>\n

Gardasil<\/a>, the most commonly used HPV vaccine between 2009 and 2016, protects against infection with four HPV types\u2014two that cause most HPV-related cancers and two that cause genital warts. HPV vaccination has been routinely recommended for girls since 2006 and for boys since 2011.<\/p>\n

During the time period of the study, HPV vaccination rates rose from 0% to 6% for men and from 7% to 15% for women, the researchers found. Meanwhile, the prevalence of oral infections from the four HPV types covered by Gardasil went down by 37% among unvaccinated men in the study. The prevalence of oral infections with HPV types not covered by the vaccine, however, didn\u2019t change.<\/p>\n

Among unvaccinated women in the study, the prevalence of oral infections with all HPV types\u2014both covered and not covered by Gardasil\u2014didn\u2019t change, the researchers found. Oral HPV infections were less common in women, making the rates too low to reliably estimate any changes over time, Dr. Chaturvedi explained.<\/p>\n

Relying on participants to recall information about their vaccination status is a limitation of the study, Dr. Zimet pointed out. \u201cIt\u2019s not the best way to assess whether someone has been vaccinated, but it is largely accurate and there\u2019s no way to get around it \u2026 for this kind of study,\u201d he said.<\/p>\n

What This Means for HPV Vaccination<\/h2>\n

Although this study suggests that people who get vaccinated against HPV may provide some protection to those who don\u2019t, that doesn\u2019t mean that people should skip the vaccine, Dr. Chaturvedi noted.<\/p>\n

These findings provide \u201cpreliminary evidence for a limited degree of herd protection that is much smaller than the direct benefit of getting vaccinated,\u201d he stressed. Getting the HPV vaccine provides near complete protection from several cancer-causing types of HPV, he explained.<\/p>\n

However, there are some people for whom herd protection is critical, Dr. Zimet noted, such as those who have an immune system disorder<\/a> that precludes them from getting vaccinated or mounting a sufficient immune response<\/a> to the vaccine.<\/p>\n

\u201cEstablishing herd protection is really a social responsibility,\u201d he said.<\/p>\n

The bottom line, then, is that \u201cevery eligible individual should get vaccinated,\u201d Dr. Chaturvedi said. CDC\u2019s Advisory Committee on Immunization Practices recommends HPV vaccination<\/a> for all boys and girls at age 11 or 12, and for people through age 26 if they weren\u2019t already vaccinated.<\/p>\n

But according to data from 2018, only 51% of teens have completed the HPV vaccine series<\/a>, Dr. Zimet noted. A goal of Healthy People 2020<\/a>, a government-led initiative to improve the health of all Americans, is to reach an 80% vaccination rate for HPV by the year 2020.<\/p>\n

\u201cWe\u2019re a long way from that,\u201d he said.<\/p>\n